YBX1: an RNA/DNA-binding protein that affects disease progression
YBX1 is a member of the Y-box transcription factor family and is a multifunctional RNA/DNA-binding protein characterized by a highly conserved cold shock domain (CSD). YBX1 is localized in both the cytoplasm and nucleus, where it participates in various biological processes such as transcription, tr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1635209/full |
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| author | Xifeng Zheng Xifeng Zheng Feng Zeng Yan Lei Yanling Li Jun Deng Gengqiu Luo Qian He Yanhong Zhou |
| author_facet | Xifeng Zheng Xifeng Zheng Feng Zeng Yan Lei Yanling Li Jun Deng Gengqiu Luo Qian He Yanhong Zhou |
| author_sort | Xifeng Zheng |
| collection | DOAJ |
| description | YBX1 is a member of the Y-box transcription factor family and is a multifunctional RNA/DNA-binding protein characterized by a highly conserved cold shock domain (CSD). YBX1 is localized in both the cytoplasm and nucleus, where it participates in various biological processes such as transcription, translation, and DNA damage repair. YBX1 is upregulated in numerous malignant tumors and is closely associated with tumor progression and poor prognosis, making it a recognized target for cancer therapy. This review introduces the role and mechanism of YBX1 in tumor progression, its function in embryonic development, bone differentiation, cartilage formation, and adipogenesis, the impact of upstream regulatory factors on its function, as well as the relationship between YBX1 and disease prognosis and treatment outcomes. This review aims to provide a comprehensive perspective on the function of YBX1. |
| format | Article |
| id | doaj-art-b0f7dfabdb294ffa9eea2b573e8c74f7 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-b0f7dfabdb294ffa9eea2b573e8c74f72025-08-20T03:08:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.16352091635209YBX1: an RNA/DNA-binding protein that affects disease progressionXifeng Zheng0Xifeng Zheng1Feng Zeng2Yan Lei3Yanling Li4Jun Deng5Gengqiu Luo6Qian He7Yanhong Zhou8Department of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan, ChinaCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, ChinaCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan, ChinaDepartment of Nuclear Medicine, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, ChinaDepartment of Early Clinical Trail Center, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan, ChinaDepartment of Pathology, Xiangya Hospital, Basic School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan, ChinaCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan, ChinaYBX1 is a member of the Y-box transcription factor family and is a multifunctional RNA/DNA-binding protein characterized by a highly conserved cold shock domain (CSD). YBX1 is localized in both the cytoplasm and nucleus, where it participates in various biological processes such as transcription, translation, and DNA damage repair. YBX1 is upregulated in numerous malignant tumors and is closely associated with tumor progression and poor prognosis, making it a recognized target for cancer therapy. This review introduces the role and mechanism of YBX1 in tumor progression, its function in embryonic development, bone differentiation, cartilage formation, and adipogenesis, the impact of upstream regulatory factors on its function, as well as the relationship between YBX1 and disease prognosis and treatment outcomes. This review aims to provide a comprehensive perspective on the function of YBX1.https://www.frontiersin.org/articles/10.3389/fonc.2025.1635209/fullYBX1tumor metastasischemotherapy resistanceRNA stabilitynon-coding RNA interactions |
| spellingShingle | Xifeng Zheng Xifeng Zheng Feng Zeng Yan Lei Yanling Li Jun Deng Gengqiu Luo Qian He Yanhong Zhou YBX1: an RNA/DNA-binding protein that affects disease progression Frontiers in Oncology YBX1 tumor metastasis chemotherapy resistance RNA stability non-coding RNA interactions |
| title | YBX1: an RNA/DNA-binding protein that affects disease progression |
| title_full | YBX1: an RNA/DNA-binding protein that affects disease progression |
| title_fullStr | YBX1: an RNA/DNA-binding protein that affects disease progression |
| title_full_unstemmed | YBX1: an RNA/DNA-binding protein that affects disease progression |
| title_short | YBX1: an RNA/DNA-binding protein that affects disease progression |
| title_sort | ybx1 an rna dna binding protein that affects disease progression |
| topic | YBX1 tumor metastasis chemotherapy resistance RNA stability non-coding RNA interactions |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1635209/full |
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