The hexapeptide functionalized gold nanoparticles protect against sepsis-associated encephalopathy by forming specific protein corona and regulating macrophage activation

The hexapeptide functionalized gold nanoparticles protect against sepsis-associated encephalopathy by forming specific protein corona and regulating macrophage activation

Sepsis-induced systemic inflammatory responses can often lead to brain dysfunction with impaired cognitive function and mobility, known as sepsis-associated encephalopathy (SAE). Currently, there are no effective pharmacological therapeutics to treat SAE. Herein, we demonstrated the hexapeptide func...

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Bibliographic Details
Main Authors: Zichen Song, Hongguang Chen, Wenfei Xu, Xiaoye Zong, Xiaoyu Wang, Yuting Ji, Jiameng Gong, Mimi Pang, Shan-Yu Fung, Hong Yang, Yonghao Yu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Sepsis-associated encephalopathy
Bioactive nanoparticles
Protein corona
Monocyte/macrophage
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425002637
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