Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation
Asthma is a complex, multifactorial inflammatory disorder of the airways, characterized by recurrent symptoms and variable airflow obstruction. So far, two main asthma endotypes have been identified, type 2 (T2)-high or T2-low, based on the underlying immunological mechanisms. Recently, extracellula...
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MDPI AG
2025-04-01
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| Online Access: | https://www.mdpi.com/2073-4409/14/7/542 |
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| author | Naila Arif Cheema Annalisa Castagna Francesca Ambrosani Giuseppe Argentino Simonetta Friso Marco Zurlo Ruggero Beri Matteo Maule Rachele Vaia Gianenrico Senna Marco Caminati |
| author_facet | Naila Arif Cheema Annalisa Castagna Francesca Ambrosani Giuseppe Argentino Simonetta Friso Marco Zurlo Ruggero Beri Matteo Maule Rachele Vaia Gianenrico Senna Marco Caminati |
| author_sort | Naila Arif Cheema |
| collection | DOAJ |
| description | Asthma is a complex, multifactorial inflammatory disorder of the airways, characterized by recurrent symptoms and variable airflow obstruction. So far, two main asthma endotypes have been identified, type 2 (T2)-high or T2-low, based on the underlying immunological mechanisms. Recently, extracellular vesicles (EVs), particularly exosomes, have gained increasing attention due to their pivotal role in intercellular communication and distal signaling modulation. In the context of asthma pathobiology, an increasing amount of experimental evidence suggests that EVs secreted by eosinophils, mast cells, dendritic cells, T cells, neutrophils, macrophages, and epithelial cells contribute to disease modulation. This review explores the role of EVs in profiling the molecular signatures of T2-high and T2-low asthma, offering novel perspectives on disease mechanisms and potential therapeutic targets. |
| format | Article |
| id | doaj-art-b0f0d4dbbe7949ff8a72bc20fc7a80b4 |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-b0f0d4dbbe7949ff8a72bc20fc7a80b42025-08-20T03:08:46ZengMDPI AGCells2073-44092025-04-0114754210.3390/cells14070542Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 InflammationNaila Arif Cheema0Annalisa Castagna1Francesca Ambrosani2Giuseppe Argentino3Simonetta Friso4Marco Zurlo5Ruggero Beri6Matteo Maule7Rachele Vaia8Gianenrico Senna9Marco Caminati10Department of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyDepartment of Medicine, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyAsthma is a complex, multifactorial inflammatory disorder of the airways, characterized by recurrent symptoms and variable airflow obstruction. So far, two main asthma endotypes have been identified, type 2 (T2)-high or T2-low, based on the underlying immunological mechanisms. Recently, extracellular vesicles (EVs), particularly exosomes, have gained increasing attention due to their pivotal role in intercellular communication and distal signaling modulation. In the context of asthma pathobiology, an increasing amount of experimental evidence suggests that EVs secreted by eosinophils, mast cells, dendritic cells, T cells, neutrophils, macrophages, and epithelial cells contribute to disease modulation. This review explores the role of EVs in profiling the molecular signatures of T2-high and T2-low asthma, offering novel perspectives on disease mechanisms and potential therapeutic targets.https://www.mdpi.com/2073-4409/14/7/542asthmaTh2T2 inflammationextracellular vesiclesexosomespersonalized medicine |
| spellingShingle | Naila Arif Cheema Annalisa Castagna Francesca Ambrosani Giuseppe Argentino Simonetta Friso Marco Zurlo Ruggero Beri Matteo Maule Rachele Vaia Gianenrico Senna Marco Caminati Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation Cells asthma Th2 T2 inflammation extracellular vesicles exosomes personalized medicine |
| title | Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation |
| title_full | Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation |
| title_fullStr | Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation |
| title_full_unstemmed | Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation |
| title_short | Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation |
| title_sort | extracellular vesicles in asthma intercellular cross talk in th2 inflammation |
| topic | asthma Th2 T2 inflammation extracellular vesicles exosomes personalized medicine |
| url | https://www.mdpi.com/2073-4409/14/7/542 |
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