Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization
Background: Central nervous system (CNS) diseases pose significant therapeutic challenges owing to their complex pathophysiology and the restrictive nature of the blood-brain barrier (BBB).Introduction: Plant-derived exosome-like nanoparticles (PDELNs) exhibit intrinsic bioactivity, low immunogenici...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2537345 |
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| author | Mengmeng Liu Hongli Wang Yizhuang Yang Jianhua Wang Zhen Sun Shiyuan Zhao Weihua Kong Wenxue Sun Cuiyun Wang Lei Feng |
| author_facet | Mengmeng Liu Hongli Wang Yizhuang Yang Jianhua Wang Zhen Sun Shiyuan Zhao Weihua Kong Wenxue Sun Cuiyun Wang Lei Feng |
| author_sort | Mengmeng Liu |
| collection | DOAJ |
| description | Background: Central nervous system (CNS) diseases pose significant therapeutic challenges owing to their complex pathophysiology and the restrictive nature of the blood-brain barrier (BBB).Introduction: Plant-derived exosome-like nanoparticles (PDELNs) exhibit intrinsic bioactivity, low immunogenicity, and ability to cross the BBB, making them a promising therapeutic strategy for CNS disorders.Discussion: This review explores the preparation, isolation, and characterization of PDELNs, with a focus on their therapeutic applications in CNS diseases. We also discuss different administration routes and the impact of functional modifications on BBB penetration.Conclusions: PDELNs offer scalability, biocompatibility, and natural pharmacological activity, which make them attractive candidates for CNS drug delivery. However, challenges remain, including standardized isolation, elucidation of BBB penetration mechanisms, and long-term stability and safety. Future research should focus on clarifying their mechanisms of action, optimizing preparation methods, and validating their long-term safety to facilitate the clinical translation of PDELNs.KEY MESSAGESPDELNs are derived from abundant plant sources, exhibit favorable physicochemical properties.PDELNs offer new possibilities for CNS therapies owing to their low immunogenicity, high biocompatibility, and ability to cross the BBB. |
| format | Article |
| id | doaj-art-b0efb620522e4cccb2732bd482a454b9 |
| institution | DOAJ |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-b0efb620522e4cccb2732bd482a454b92025-08-20T03:09:19ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2537345Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterizationMengmeng Liu0Hongli Wang1Yizhuang Yang2Jianhua Wang3Zhen Sun4Shiyuan Zhao5Weihua Kong6Wenxue Sun7Cuiyun Wang8Lei Feng9Department of Pharmacy, Jining No. 1 People’s Hospital, Shandong First Medical University, Jining, ChinaDepartment of Pharmacy, Jining No. 1 People’s Hospital, Shandong First Medical University, Jining, ChinaDepartment of Pharmacy, Guilin Medical University, Guilin, ChinaShandong University of Traditional Chinese Medicine, Jinan, ChinaTranslational Pharmaceutical Laboratory, Jining No. 1 People’s Hospital, Shandong First Medical University, Jining, ChinaTranslational Pharmaceutical Laboratory, Jining No. 1 People’s Hospital, Shandong First Medical University, Jining, ChinaDepartment of Neurosurgery, Jining No.1 People’s Hospital, Shandong First Medical University, Jining, ChinaShandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Pharmacy, Jining No. 1 People’s Hospital, Shandong First Medical University, Jining, ChinaDepartment of Neurosurgery, Jining No.1 People’s Hospital, Shandong First Medical University, Jining, ChinaBackground: Central nervous system (CNS) diseases pose significant therapeutic challenges owing to their complex pathophysiology and the restrictive nature of the blood-brain barrier (BBB).Introduction: Plant-derived exosome-like nanoparticles (PDELNs) exhibit intrinsic bioactivity, low immunogenicity, and ability to cross the BBB, making them a promising therapeutic strategy for CNS disorders.Discussion: This review explores the preparation, isolation, and characterization of PDELNs, with a focus on their therapeutic applications in CNS diseases. We also discuss different administration routes and the impact of functional modifications on BBB penetration.Conclusions: PDELNs offer scalability, biocompatibility, and natural pharmacological activity, which make them attractive candidates for CNS drug delivery. However, challenges remain, including standardized isolation, elucidation of BBB penetration mechanisms, and long-term stability and safety. Future research should focus on clarifying their mechanisms of action, optimizing preparation methods, and validating their long-term safety to facilitate the clinical translation of PDELNs.KEY MESSAGESPDELNs are derived from abundant plant sources, exhibit favorable physicochemical properties.PDELNs offer new possibilities for CNS therapies owing to their low immunogenicity, high biocompatibility, and ability to cross the BBB.https://www.tandfonline.com/doi/10.1080/07853890.2025.2537345Exosomesplant-derived exosome-like nanoparticlesCNS diseasesdrug delivery systems |
| spellingShingle | Mengmeng Liu Hongli Wang Yizhuang Yang Jianhua Wang Zhen Sun Shiyuan Zhao Weihua Kong Wenxue Sun Cuiyun Wang Lei Feng Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization Annals of Medicine Exosomes plant-derived exosome-like nanoparticles CNS diseases drug delivery systems |
| title | Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization |
| title_full | Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization |
| title_fullStr | Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization |
| title_full_unstemmed | Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization |
| title_short | Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization |
| title_sort | therapeutic potential of plant derived exosome like nanoparticles for cns diseases advancements in preparation and characterization |
| topic | Exosomes plant-derived exosome-like nanoparticles CNS diseases drug delivery systems |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2537345 |
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