EVALUATION OF THE THROMBOGENICITY OF THE VASCULAR ENDOTHELIUM IN PATIENTS IN THE ACUTE PHASE OF THE ISCHEMIC STROKE
Objective: To assess the thrombogenicity of the vascular endothelium based on laboratory parameters in patients in the acute phase of the ischemic stroke (IS), depending on the subtype of IS. Methods: The study involved 51 patients with the first diagnosed IS confirmed by CT/MRI of the brain with...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Avicenna Tajik State Medical University
2025-03-01
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| Series: | Паёми Сино |
| Subjects: | |
| Online Access: | https://doi.org/10.25005/2074-0581-2025-27-1-33-45 |
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| Summary: | Objective: To assess the thrombogenicity of the vascular endothelium based on laboratory parameters in patients in the acute phase of the ischemic stroke (IS), depending on the subtype of IS.
Methods: The study involved 51 patients with the first diagnosed IS confirmed by CT/MRI of the brain within 24 hours from the onset of the disease and 20 healthy individuals (control group). D-dimer, von Willebrand factor (vWF) activity, fibrinogen, C-reactive protein (CRP), lipid profile (total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), atherogenic index, triglycerides, very-low-density lipoproteins (VLDL), and the total cholesterol to HDL ratio) were measured to evaluate the thrombogenicity of the vascular endothelium. The clinical course of IS was assessed using the NIHSS, Rivermead, and Rankin scales.
Results: Significant changes in the thrombogenicity of the vascular endothelium were observed in most IS patients, particularly in those with atherothrombotic and cardioembolic subtypes. These changes were assessed through D-dimer levels, vWF activity, and lipid profile parameters, which significantly correlated with age, body mass index (BMI), blood pressure, and clinical severity of neurological damage. The results of factor and regression analysis showed their prognostic significance.
Conclusion: Deviations in the thrombogenicity of the vascular endothelium amidst inflammatory changes in the vessel wall during the acute IS period occur in most patients and have prognostic significance. |
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| ISSN: | 2074-0581 2959-6327 |