MicroRNA Signatures in Endometrial Receptivity—Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic Review
<b>Background:</b> Endometrial receptivity is crucial for successful embryo implantation in assisted reproductive technologies (ARTs). MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have emerged as important post-transcriptional regulators of endometrial...
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2025-05-01
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| author | Charalampos Voros Antonia Varthaliti Diamantis Athanasiou Despoina Mavrogianni Kyriakos Bananis Antonia Athanasiou Aikaterini Athanasiou Anthi-Maria Papahliou Constantinos G. Zografos Panagiota Kondili Maria Anastasia Daskalaki Dimitris Mazis Kourakos Dimitrios Vaitsis Marianna Theodora Panagiotis Antsaklis Dimitrios Loutradis Georgios Daskalakis |
| author_facet | Charalampos Voros Antonia Varthaliti Diamantis Athanasiou Despoina Mavrogianni Kyriakos Bananis Antonia Athanasiou Aikaterini Athanasiou Anthi-Maria Papahliou Constantinos G. Zografos Panagiota Kondili Maria Anastasia Daskalaki Dimitris Mazis Kourakos Dimitrios Vaitsis Marianna Theodora Panagiotis Antsaklis Dimitrios Loutradis Georgios Daskalakis |
| author_sort | Charalampos Voros |
| collection | DOAJ |
| description | <b>Background:</b> Endometrial receptivity is crucial for successful embryo implantation in assisted reproductive technologies (ARTs). MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have emerged as important post-transcriptional regulators of endometrial function, although their diagnostic and molecular functions are poorly understood. <b>Methods:</b> A systematic review was conducted following PRISMA 2020 principles and registered in PROSPERO (CRD420251001811). We looked at 28 peer-reviewed publications published between 2010 and 2025 that used endometrial tissue, blood, uterine fluid, saliva, and embryo culture medium to study miRNAs and other non-coding RNAs in endometrial receptivity, recurrent implantation failure (RIF), and infertility. <b>Results:</b> MiRNAs like miR-145, miR-30d, miR-223-3p, and miR-125b influence implantation-related pathways such as HOXA10, LIF-STAT3, PI3K-Akt, and Wnt/β-catenin. Dysregulated expression profiles were linked to inadequate decidualization, immunological imbalance, and poor angiogenesis. CeRNA networks that include lncRNAs (e.g., H19 and NEAT1) and circRNAs (e.g., circ_0038383) further regulate miRNA activity. Non-invasive biomarkers derived from plasma, uterine fluid, and embryo media showed high prediction accuracy for implantation outcomes. <b>Conclusions:</b> MiRNA signatures offer a functional and diagnostic blueprint for endometrial receptivity. This systematic review provides a timely and thorough synthesis of the existing literature, with the goal of bridging the gap between molecular discoveries and therapeutic applications. By emphasizing both the mechanistic importance and diagnostic value of certain miRNA signatures, it paves the way for future precision-based techniques in embryo transfer and endometrial assessment in ART. |
| format | Article |
| id | doaj-art-b0e42228adda4b08927f1a7b8473dcab |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-b0e42228adda4b08927f1a7b8473dcab2025-08-20T03:14:30ZengMDPI AGBiomedicines2227-90592025-05-01135118910.3390/biomedicines13051189MicroRNA Signatures in Endometrial Receptivity—Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic ReviewCharalampos Voros0Antonia Varthaliti1Diamantis Athanasiou2Despoina Mavrogianni3Kyriakos Bananis4Antonia Athanasiou5Aikaterini Athanasiou6Anthi-Maria Papahliou7Constantinos G. Zografos8Panagiota Kondili9Maria Anastasia Daskalaki10Dimitris Mazis Kourakos11Dimitrios Vaitsis12Marianna Theodora13Panagiotis Antsaklis14Dimitrios Loutradis15Georgios Daskalakis161st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, GreeceIVF Athens Reproduction Center V. Athanasiou, 15123 Maroussi, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, GreeceKing’s College Hospitals NHS Foundation Trust, London SE5 9RS, UKIVF Athens Reproduction Center V. Athanasiou, 15123 Maroussi, GreeceIVF Athens Reproduction Center V. Athanasiou, 15123 Maroussi, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece2nd Surgical Department, General Hospital of Athens “LAIKO”, 11527 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, GreeceRea Maternity Hospital S.A., Avenue Siggrou 383 & Pentelis 17, P. Faliro, 17564 Athens, GreeceAthens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, GreeceAthens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece1st Department of Obstetrics and Gynecology, ‘Alexandra’ General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece<b>Background:</b> Endometrial receptivity is crucial for successful embryo implantation in assisted reproductive technologies (ARTs). MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have emerged as important post-transcriptional regulators of endometrial function, although their diagnostic and molecular functions are poorly understood. <b>Methods:</b> A systematic review was conducted following PRISMA 2020 principles and registered in PROSPERO (CRD420251001811). We looked at 28 peer-reviewed publications published between 2010 and 2025 that used endometrial tissue, blood, uterine fluid, saliva, and embryo culture medium to study miRNAs and other non-coding RNAs in endometrial receptivity, recurrent implantation failure (RIF), and infertility. <b>Results:</b> MiRNAs like miR-145, miR-30d, miR-223-3p, and miR-125b influence implantation-related pathways such as HOXA10, LIF-STAT3, PI3K-Akt, and Wnt/β-catenin. Dysregulated expression profiles were linked to inadequate decidualization, immunological imbalance, and poor angiogenesis. CeRNA networks that include lncRNAs (e.g., H19 and NEAT1) and circRNAs (e.g., circ_0038383) further regulate miRNA activity. Non-invasive biomarkers derived from plasma, uterine fluid, and embryo media showed high prediction accuracy for implantation outcomes. <b>Conclusions:</b> MiRNA signatures offer a functional and diagnostic blueprint for endometrial receptivity. This systematic review provides a timely and thorough synthesis of the existing literature, with the goal of bridging the gap between molecular discoveries and therapeutic applications. By emphasizing both the mechanistic importance and diagnostic value of certain miRNA signatures, it paves the way for future precision-based techniques in embryo transfer and endometrial assessment in ART.https://www.mdpi.com/2227-9059/13/5/1189endometrial receptivitymicroRNAsimplantation failureassisted reproductive technology (ART)embryo implantationlncRNAs |
| spellingShingle | Charalampos Voros Antonia Varthaliti Diamantis Athanasiou Despoina Mavrogianni Kyriakos Bananis Antonia Athanasiou Aikaterini Athanasiou Anthi-Maria Papahliou Constantinos G. Zografos Panagiota Kondili Maria Anastasia Daskalaki Dimitris Mazis Kourakos Dimitrios Vaitsis Marianna Theodora Panagiotis Antsaklis Dimitrios Loutradis Georgios Daskalakis MicroRNA Signatures in Endometrial Receptivity—Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic Review Biomedicines endometrial receptivity microRNAs implantation failure assisted reproductive technology (ART) embryo implantation lncRNAs |
| title | MicroRNA Signatures in Endometrial Receptivity—Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic Review |
| title_full | MicroRNA Signatures in Endometrial Receptivity—Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic Review |
| title_fullStr | MicroRNA Signatures in Endometrial Receptivity—Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic Review |
| title_full_unstemmed | MicroRNA Signatures in Endometrial Receptivity—Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic Review |
| title_short | MicroRNA Signatures in Endometrial Receptivity—Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic Review |
| title_sort | microrna signatures in endometrial receptivity unlocking their role in embryo implantation and ivf success a systematic review |
| topic | endometrial receptivity microRNAs implantation failure assisted reproductive technology (ART) embryo implantation lncRNAs |
| url | https://www.mdpi.com/2227-9059/13/5/1189 |
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