PSD3 as a context-dependent modulator of immune landscape and tumor aggressiveness in esophageal squamous cell carcinoma

PSD3 as a context-dependent modulator of immune landscape and tumor aggressiveness in esophageal squamous cell carcinoma

In this study, we investigated PSD3, CD274 (PD-L1), and TNFSF18 as potential immune-related biomarkers in esophageal squamous cell carcinoma (ESCC) using integrative transcriptomic and experimental approaches. CD274 and TNFSF18 were consistently up-regulated in ESCC across both TCGA and GEO datasets...

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Bibliographic Details
Main Authors: Shujuan Luo, Huifang Li, Bangwu Cai, Aididar Nurbahati, Hong Cui, Tianyuan Peng, Wei Wang, Qing Liu, Xiaomei Lu, Shutao Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
esophageal squamous cell carcinoma
PSD3
PD-L1
TNFSF18
tumor microenvironment
immune infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1641254/full
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