Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine Tumors
<b>Background:</b> Neuroendocrine tumors are tumors that can develop in any organ but show a predilection for the pancreas. These can be secreting or non-secreting tumors, or they can be well differentiated or poorly differentiated, or neuroendocrine carcinomas. Surgical treatment is the...
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2025-01-01
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| author | Nutu Vlad Florina Delia Andriesi-Rusu Andrei Chicos Ana Maria Trofin Ramona Cadar Mihai Lucian Zabara Delia Ciobanu Mircea Costache Corina Lupascu-Ursulescu Alin Mihai Vasilescu Costel Bradea Mihaela Blaj Oana Maria Lovin Adi Ionut Ciumanghel Felicia Crumpei Cristian Dumitru Lupascu |
| author_facet | Nutu Vlad Florina Delia Andriesi-Rusu Andrei Chicos Ana Maria Trofin Ramona Cadar Mihai Lucian Zabara Delia Ciobanu Mircea Costache Corina Lupascu-Ursulescu Alin Mihai Vasilescu Costel Bradea Mihaela Blaj Oana Maria Lovin Adi Ionut Ciumanghel Felicia Crumpei Cristian Dumitru Lupascu |
| author_sort | Nutu Vlad |
| collection | DOAJ |
| description | <b>Background:</b> Neuroendocrine tumors are tumors that can develop in any organ but show a predilection for the pancreas. These can be secreting or non-secreting tumors, or they can be well differentiated or poorly differentiated, or neuroendocrine carcinomas. Surgical treatment is the only treatment with curative intent, but postoperatively, it shows an increased incidence of postoperative pancreatic fistulas. <b>Methods:</b> We carried out a retrospective study which included 26 patients with neuroendocrine tumors and neuroendocrine carcinomas, for whom we performed cephalic duodenopancreatectomies, distal pancreatic resections or enucleation. <b>Results:</b> In our study group, the incidence of pancreatic fistulas was 28%, and a series of risk factors such as the type of surgery (duodenopancreatectomy and enucleation were associated with the highest incidence of POPF), histological type (pancreatic neuroendocrine carcinomas were associated with lowest incidence of POPF), obesity (the incidence of POPF was double in the obese group), functioning tumors (with <i>p</i> = 0.032 and AUC = 746) and dynamic hemoglobin value (AUC = 705 shows a good predicting power, with a cutoff value = 1.8 drop hemoglobin) were indicated. <b>Conclusions:</b> Neuroendocrine tumors show a predisposition for the occurrence of postoperative complications, especially postoperative pancreatic fistulas. There are multiple risk factors that interact in the production of postoperative complications. |
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| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-b0dedc88d78f4030bab07899ea7983912025-08-20T02:12:24ZengMDPI AGDiagnostics2075-44182025-01-0115326810.3390/diagnostics15030268Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine TumorsNutu Vlad0Florina Delia Andriesi-Rusu1Andrei Chicos2Ana Maria Trofin3Ramona Cadar4Mihai Lucian Zabara5Delia Ciobanu6Mircea Costache7Corina Lupascu-Ursulescu8Alin Mihai Vasilescu9Costel Bradea10Mihaela Blaj11Oana Maria Lovin12Adi Ionut Ciumanghel13Felicia Crumpei14Cristian Dumitru Lupascu15First Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFaculty of Medicine, ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFaculty of Medicine, ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFaculty of Medicine, ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFaculty of Medicine, ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFaculty of Medicine, ”Grigore T. Popa” University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, RomaniaFirst Surgical Clinic, “St. Spiridon” Hospital Iasi, Independentei str, no 1, 700111 Iasi, Romania<b>Background:</b> Neuroendocrine tumors are tumors that can develop in any organ but show a predilection for the pancreas. These can be secreting or non-secreting tumors, or they can be well differentiated or poorly differentiated, or neuroendocrine carcinomas. Surgical treatment is the only treatment with curative intent, but postoperatively, it shows an increased incidence of postoperative pancreatic fistulas. <b>Methods:</b> We carried out a retrospective study which included 26 patients with neuroendocrine tumors and neuroendocrine carcinomas, for whom we performed cephalic duodenopancreatectomies, distal pancreatic resections or enucleation. <b>Results:</b> In our study group, the incidence of pancreatic fistulas was 28%, and a series of risk factors such as the type of surgery (duodenopancreatectomy and enucleation were associated with the highest incidence of POPF), histological type (pancreatic neuroendocrine carcinomas were associated with lowest incidence of POPF), obesity (the incidence of POPF was double in the obese group), functioning tumors (with <i>p</i> = 0.032 and AUC = 746) and dynamic hemoglobin value (AUC = 705 shows a good predicting power, with a cutoff value = 1.8 drop hemoglobin) were indicated. <b>Conclusions:</b> Neuroendocrine tumors show a predisposition for the occurrence of postoperative complications, especially postoperative pancreatic fistulas. There are multiple risk factors that interact in the production of postoperative complications.https://www.mdpi.com/2075-4418/15/3/268pancreatic neuroendocrine tumorspancreatic neuroendocrine carcinomaspancreatic resectionspostoperative pancreatic fistulaprognostic factors |
| spellingShingle | Nutu Vlad Florina Delia Andriesi-Rusu Andrei Chicos Ana Maria Trofin Ramona Cadar Mihai Lucian Zabara Delia Ciobanu Mircea Costache Corina Lupascu-Ursulescu Alin Mihai Vasilescu Costel Bradea Mihaela Blaj Oana Maria Lovin Adi Ionut Ciumanghel Felicia Crumpei Cristian Dumitru Lupascu Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine Tumors Diagnostics pancreatic neuroendocrine tumors pancreatic neuroendocrine carcinomas pancreatic resections postoperative pancreatic fistula prognostic factors |
| title | Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine Tumors |
| title_full | Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine Tumors |
| title_fullStr | Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine Tumors |
| title_full_unstemmed | Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine Tumors |
| title_short | Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine Tumors |
| title_sort | predicting factor for occurrence of postoperative pancreatic fistula in patients with pancreatic neuroendocrine tumors |
| topic | pancreatic neuroendocrine tumors pancreatic neuroendocrine carcinomas pancreatic resections postoperative pancreatic fistula prognostic factors |
| url | https://www.mdpi.com/2075-4418/15/3/268 |
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