Condensate dynamics at the synapse: Phase separation tunes presynaptic function.
A new study in PLOS Biology shows that Liprin-α and RIM form condensates which not only scaffold presynaptic protein architectures but also fine-tune vesicle priming and release dynamics.
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-06-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3003201 |
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| _version_ | 1849693819922022400 |
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| author | Janine Lützkendorf Stephan J Sigrist |
| author_facet | Janine Lützkendorf Stephan J Sigrist |
| author_sort | Janine Lützkendorf |
| collection | DOAJ |
| description | A new study in PLOS Biology shows that Liprin-α and RIM form condensates which not only scaffold presynaptic protein architectures but also fine-tune vesicle priming and release dynamics. |
| format | Article |
| id | doaj-art-b0dd161978d44fbd9249723d3c21a7fb |
| institution | DOAJ |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-b0dd161978d44fbd9249723d3c21a7fb2025-08-20T03:20:16ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852025-06-01236e300320110.1371/journal.pbio.3003201Condensate dynamics at the synapse: Phase separation tunes presynaptic function.Janine LützkendorfStephan J SigristA new study in PLOS Biology shows that Liprin-α and RIM form condensates which not only scaffold presynaptic protein architectures but also fine-tune vesicle priming and release dynamics.https://doi.org/10.1371/journal.pbio.3003201 |
| spellingShingle | Janine Lützkendorf Stephan J Sigrist Condensate dynamics at the synapse: Phase separation tunes presynaptic function. PLoS Biology |
| title | Condensate dynamics at the synapse: Phase separation tunes presynaptic function. |
| title_full | Condensate dynamics at the synapse: Phase separation tunes presynaptic function. |
| title_fullStr | Condensate dynamics at the synapse: Phase separation tunes presynaptic function. |
| title_full_unstemmed | Condensate dynamics at the synapse: Phase separation tunes presynaptic function. |
| title_short | Condensate dynamics at the synapse: Phase separation tunes presynaptic function. |
| title_sort | condensate dynamics at the synapse phase separation tunes presynaptic function |
| url | https://doi.org/10.1371/journal.pbio.3003201 |
| work_keys_str_mv | AT janinelutzkendorf condensatedynamicsatthesynapsephaseseparationtunespresynapticfunction AT stephanjsigrist condensatedynamicsatthesynapsephaseseparationtunespresynapticfunction |