The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population
Objective. We aimed to determine the prevalence of specific auto-antibodies to celiac disease (CD) in Moroccan type 1 diabetic (T1D) patients and compare the clinical and biological characteristics of seropositive and seronegative cases. Patients and Methods. A cross-sectional study was carried out...
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/7895207 |
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| author | Ider Oujamaa Majda Sebbani Lahcen Elmoumou Aïcha Bourrahouate Rabiy El Qadiry Soufian El Moussaoui Imane Ait Sab Mohamed Sbihi Laila Ennazk Ghizlane El Mghari-Tabib Nawal El Ansari Hicham Baizri Mohamed Amine Brahim Admou |
| author_facet | Ider Oujamaa Majda Sebbani Lahcen Elmoumou Aïcha Bourrahouate Rabiy El Qadiry Soufian El Moussaoui Imane Ait Sab Mohamed Sbihi Laila Ennazk Ghizlane El Mghari-Tabib Nawal El Ansari Hicham Baizri Mohamed Amine Brahim Admou |
| author_sort | Ider Oujamaa |
| collection | DOAJ |
| description | Objective. We aimed to determine the prevalence of specific auto-antibodies to celiac disease (CD) in Moroccan type 1 diabetic (T1D) patients and compare the clinical and biological characteristics of seropositive and seronegative cases. Patients and Methods. A cross-sectional study was carried out on 276 T1D patients including 109 adults and 167 pediatric cases. The screening for CD was performed by an Elisa IgA anti-tissue transglutaminase antibody (tTGA) testing, combined with IgA quantification by nephelometry. Positive-IgA-tTGA cases were secondly tested for anti-endomysial antibodies (EMA) using an immunofluorescence technique, and the IgA deficiency cases were screened for IgG-tTGA. Patients with low positive tTGA titers underwent HLA-DQ2/DQ8 typing. Sociodemographic and clinical data of the patients were collected using a hetero-administered questionnaire. The comparison of clinical and biological data between seropositive and seronegative diabetics was done using independent T, Mann–Whitney U, chi-squared, and Fisher tests, which were considered significant if p value <0.05. Results. The prevalence of CD-specific auto-antibodies was estimated to be 9.1% (IC = 95%), with 25 positive cases in tTGA and EMA testing. Eight cases displayed low titers of IgA-tTGA, among which 4 were positive for HLA-DQ2, 1 for HLA-DQ8, and 1 for both DQ2 and DQ8. The other 2 cases had a biopsy-proven CD. Compared to seronegative patients, seropositive cases had a higher percentage of associated autoimmune disorders (16% vs. 2.4%, p=0.008), with a significant lower height Z-scores (median: −0.90 (−3.93 to 0.95) vs. −0.51 (−4.54 to 2.18), p=0.029) and a higher HbA1c level (median: 11.30% (7.31 to 16.00) vs. 9.30% (4.40 to17.31), p=0.022). Conclusion. The current study gave evidence of a high prevalence of CD specific auto-antibodies in T1D population. The co-existence of these two conditions was associated with a poor glycemic control, a lower height, and other autoimmune diseases. These findings may suggest the necessity of a systematic screening of CD in T1D patients. |
| format | Article |
| id | doaj-art-b0d4ba91e6324e3f82f579bb986b2265 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-b0d4ba91e6324e3f82f579bb986b22652025-02-03T01:28:52ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/78952077895207The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan PopulationIder Oujamaa0Majda Sebbani1Lahcen Elmoumou2Aïcha Bourrahouate3Rabiy El Qadiry4Soufian El Moussaoui5Imane Ait Sab6Mohamed Sbihi7Laila Ennazk8Ghizlane El Mghari-Tabib9Nawal El Ansari10Hicham Baizri11Mohamed Amine12Brahim Admou13Laboratory of Immunology, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Public Health and Epidemiology, PCIM Research Laboratory, Cadi Ayyad University, Marrakech, MoroccoLaboratory of Immunology, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Pediatrics, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Pediatrics, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Pediatrics, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Pediatrics, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Pediatrics, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Endocrinology, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Endocrinology, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Endocrinology, University Hospital of Marrakech, Marrakech, MoroccoDepartment of Endocrinology, Ibn Sina Military Hospital, Marrakech, MoroccoDepartment of Public Health and Epidemiology, PCIM Research Laboratory, Cadi Ayyad University, Marrakech, MoroccoLaboratory of Immunology, University Hospital of Marrakech, Marrakech, MoroccoObjective. We aimed to determine the prevalence of specific auto-antibodies to celiac disease (CD) in Moroccan type 1 diabetic (T1D) patients and compare the clinical and biological characteristics of seropositive and seronegative cases. Patients and Methods. A cross-sectional study was carried out on 276 T1D patients including 109 adults and 167 pediatric cases. The screening for CD was performed by an Elisa IgA anti-tissue transglutaminase antibody (tTGA) testing, combined with IgA quantification by nephelometry. Positive-IgA-tTGA cases were secondly tested for anti-endomysial antibodies (EMA) using an immunofluorescence technique, and the IgA deficiency cases were screened for IgG-tTGA. Patients with low positive tTGA titers underwent HLA-DQ2/DQ8 typing. Sociodemographic and clinical data of the patients were collected using a hetero-administered questionnaire. The comparison of clinical and biological data between seropositive and seronegative diabetics was done using independent T, Mann–Whitney U, chi-squared, and Fisher tests, which were considered significant if p value <0.05. Results. The prevalence of CD-specific auto-antibodies was estimated to be 9.1% (IC = 95%), with 25 positive cases in tTGA and EMA testing. Eight cases displayed low titers of IgA-tTGA, among which 4 were positive for HLA-DQ2, 1 for HLA-DQ8, and 1 for both DQ2 and DQ8. The other 2 cases had a biopsy-proven CD. Compared to seronegative patients, seropositive cases had a higher percentage of associated autoimmune disorders (16% vs. 2.4%, p=0.008), with a significant lower height Z-scores (median: −0.90 (−3.93 to 0.95) vs. −0.51 (−4.54 to 2.18), p=0.029) and a higher HbA1c level (median: 11.30% (7.31 to 16.00) vs. 9.30% (4.40 to17.31), p=0.022). Conclusion. The current study gave evidence of a high prevalence of CD specific auto-antibodies in T1D population. The co-existence of these two conditions was associated with a poor glycemic control, a lower height, and other autoimmune diseases. These findings may suggest the necessity of a systematic screening of CD in T1D patients.http://dx.doi.org/10.1155/2019/7895207 |
| spellingShingle | Ider Oujamaa Majda Sebbani Lahcen Elmoumou Aïcha Bourrahouate Rabiy El Qadiry Soufian El Moussaoui Imane Ait Sab Mohamed Sbihi Laila Ennazk Ghizlane El Mghari-Tabib Nawal El Ansari Hicham Baizri Mohamed Amine Brahim Admou The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population International Journal of Endocrinology |
| title | The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population |
| title_full | The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population |
| title_fullStr | The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population |
| title_full_unstemmed | The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population |
| title_short | The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population |
| title_sort | prevalence of celiac disease specific auto antibodies in type 1 diabetes in a moroccan population |
| url | http://dx.doi.org/10.1155/2019/7895207 |
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