Molecular pathology of microRNA-103a as a probable diagnostic and therapeutic tumor marker
Late diagnosis has a key role in therapeutic failure and tumor relapse. Therefore, assessment of the molecular tumor biology can help to introduce novel early diagnostic markers. MicroRNAs (miRNAs) have important roles in regulation of tumor cell proliferation, invasion, drug resistance, and angioge...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | Advances in Cancer Biology - Metastasis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266739402500019X |
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| author | Iman Akhlaghipour Negin Taghehchian Meysam Moghbeli |
| author_facet | Iman Akhlaghipour Negin Taghehchian Meysam Moghbeli |
| author_sort | Iman Akhlaghipour |
| collection | DOAJ |
| description | Late diagnosis has a key role in therapeutic failure and tumor relapse. Therefore, assessment of the molecular tumor biology can help to introduce novel early diagnostic markers. MicroRNAs (miRNAs) have important roles in regulation of tumor cell proliferation, invasion, drug resistance, and angiogenesis. Due to the high stability of miRNAs in paraffin-embedded tissues and body fluids, they can be also used as the non-invasive markers for cancer screening and early diagnosis. According to numerous reports about the role of miR-103a in various cancers, in the present review we investigated the molecular biology of miR-103a during tumor progression. It has been reported that miR-103a has a dual function as an oncogene and tumor suppressor in various cancers. MiR-103a exerts its role in tumor progression by regulation of signaling pathways, apoptosis, cell cycle, cell metabolism, and transcription factors. This review paves the way in introducing miR-103a as a diagnostic and therapeutic marker among cancer patients following the animal studies and clinical trials. |
| format | Article |
| id | doaj-art-b0d44f7b4ccf44cb8a0e46b3c76ea134 |
| institution | Kabale University |
| issn | 2667-3940 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Cancer Biology - Metastasis |
| spelling | doaj-art-b0d44f7b4ccf44cb8a0e46b3c76ea1342025-08-22T04:58:40ZengElsevierAdvances in Cancer Biology - Metastasis2667-39402025-12-011510015010.1016/j.adcanc.2025.100150Molecular pathology of microRNA-103a as a probable diagnostic and therapeutic tumor markerIman Akhlaghipour0Negin Taghehchian1Meysam Moghbeli2Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMedical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, IranMedical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author.Late diagnosis has a key role in therapeutic failure and tumor relapse. Therefore, assessment of the molecular tumor biology can help to introduce novel early diagnostic markers. MicroRNAs (miRNAs) have important roles in regulation of tumor cell proliferation, invasion, drug resistance, and angiogenesis. Due to the high stability of miRNAs in paraffin-embedded tissues and body fluids, they can be also used as the non-invasive markers for cancer screening and early diagnosis. According to numerous reports about the role of miR-103a in various cancers, in the present review we investigated the molecular biology of miR-103a during tumor progression. It has been reported that miR-103a has a dual function as an oncogene and tumor suppressor in various cancers. MiR-103a exerts its role in tumor progression by regulation of signaling pathways, apoptosis, cell cycle, cell metabolism, and transcription factors. This review paves the way in introducing miR-103a as a diagnostic and therapeutic marker among cancer patients following the animal studies and clinical trials.http://www.sciencedirect.com/science/article/pii/S266739402500019XmicroRNA-103aDiagnosisPrognosiscancerMarker |
| spellingShingle | Iman Akhlaghipour Negin Taghehchian Meysam Moghbeli Molecular pathology of microRNA-103a as a probable diagnostic and therapeutic tumor marker Advances in Cancer Biology - Metastasis microRNA-103a Diagnosis Prognosis cancer Marker |
| title | Molecular pathology of microRNA-103a as a probable diagnostic and therapeutic tumor marker |
| title_full | Molecular pathology of microRNA-103a as a probable diagnostic and therapeutic tumor marker |
| title_fullStr | Molecular pathology of microRNA-103a as a probable diagnostic and therapeutic tumor marker |
| title_full_unstemmed | Molecular pathology of microRNA-103a as a probable diagnostic and therapeutic tumor marker |
| title_short | Molecular pathology of microRNA-103a as a probable diagnostic and therapeutic tumor marker |
| title_sort | molecular pathology of microrna 103a as a probable diagnostic and therapeutic tumor marker |
| topic | microRNA-103a Diagnosis Prognosis cancer Marker |
| url | http://www.sciencedirect.com/science/article/pii/S266739402500019X |
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