Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3
The hair, an exclusive keratinized dermal appendage in mammals, stands as a quintessential outcome of adaptive evolution, conferring resilience against adverse environmental conditions. The ontogenesis of the coat displays a pronounced rhythmic pattern, with hair follicle stem cells (HFSCs) emerging...
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2024-12-01
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| author | Yu Zhang Xuefei Zhao Shuqi Li Yanchun Xu Suying Bai Wei Zhang |
| author_facet | Yu Zhang Xuefei Zhao Shuqi Li Yanchun Xu Suying Bai Wei Zhang |
| author_sort | Yu Zhang |
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| description | The hair, an exclusive keratinized dermal appendage in mammals, stands as a quintessential outcome of adaptive evolution, conferring resilience against adverse environmental conditions. The ontogenesis of the coat displays a pronounced rhythmic pattern, with hair follicle stem cells (HFSCs) emerging as pivotal facilitators of hair follicle reconstitution. The retinoic acid-related orphan receptor alpha, a nuclear receptor with extensive involvement in the regulation of cellular physiological states, exerts its functions predominantly through the modulation of downstream target gene transcription. The <i>Bnip3</i> gene exhibits a robust correlation with cellular apoptosis and autophagy, which are indispensable physiological mechanisms underlying the maintenance of HFSC homeostasis. Consequently, the expression level of <i>Bnip3</i> may be intimately linked to the status of HFSCs. In this investigative endeavor, we employed rat HFSCs as a model system to validate the regulatory impact of RORA on <i>Bnip3</i> gene expression. Our findings unequivocally demonstrate that <i>Bnip3</i> serves as a direct downstream target of RORA. Specifically, RORA binds to the motif within the <i>Bnip3</i> promoter region, thereby upregulating <i>Bnip3</i> expression levels. In light of our research findings, we propose that RORA holds potential as a target for modulating the status of HFSCs. |
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| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-b0d15516f1ef449ea4e5c95d4937db9d2025-08-20T01:55:34ZengMDPI AGAnimals2076-26152024-12-011423347710.3390/ani14233477Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3Yu Zhang0Xuefei Zhao1Shuqi Li2Yanchun Xu3Suying Bai4Wei Zhang5College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, ChinaCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, ChinaCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, ChinaCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, ChinaCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, ChinaCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, ChinaThe hair, an exclusive keratinized dermal appendage in mammals, stands as a quintessential outcome of adaptive evolution, conferring resilience against adverse environmental conditions. The ontogenesis of the coat displays a pronounced rhythmic pattern, with hair follicle stem cells (HFSCs) emerging as pivotal facilitators of hair follicle reconstitution. The retinoic acid-related orphan receptor alpha, a nuclear receptor with extensive involvement in the regulation of cellular physiological states, exerts its functions predominantly through the modulation of downstream target gene transcription. The <i>Bnip3</i> gene exhibits a robust correlation with cellular apoptosis and autophagy, which are indispensable physiological mechanisms underlying the maintenance of HFSC homeostasis. Consequently, the expression level of <i>Bnip3</i> may be intimately linked to the status of HFSCs. In this investigative endeavor, we employed rat HFSCs as a model system to validate the regulatory impact of RORA on <i>Bnip3</i> gene expression. Our findings unequivocally demonstrate that <i>Bnip3</i> serves as a direct downstream target of RORA. Specifically, RORA binds to the motif within the <i>Bnip3</i> promoter region, thereby upregulating <i>Bnip3</i> expression levels. In light of our research findings, we propose that RORA holds potential as a target for modulating the status of HFSCs.https://www.mdpi.com/2076-2615/14/23/3477hair follicle stem cellsretinoic acid-related orphan receptor alpha<i>Bnip3</i> |
| spellingShingle | Yu Zhang Xuefei Zhao Shuqi Li Yanchun Xu Suying Bai Wei Zhang Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3 Animals hair follicle stem cells retinoic acid-related orphan receptor alpha <i>Bnip3</i> |
| title | Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3 |
| title_full | Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3 |
| title_fullStr | Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3 |
| title_full_unstemmed | Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3 |
| title_short | Retinoic Acid-Related Orphan Receptor Alpha May Regulate the State of Hair Follicle Stem Cells by Upregulating the Expression of BNIP3 |
| title_sort | retinoic acid related orphan receptor alpha may regulate the state of hair follicle stem cells by upregulating the expression of bnip3 |
| topic | hair follicle stem cells retinoic acid-related orphan receptor alpha <i>Bnip3</i> |
| url | https://www.mdpi.com/2076-2615/14/23/3477 |
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