Comprehensive bioinformatic profiling of matrix metalloproteinases and their inhibitors: Expression and interaction patterns in head and neck cancer toward predictive biomarkers and personalized therapies

Comprehensive bioinformatic profiling of matrix metalloproteinases and their inhibitors: Expression and interaction patterns in head and neck cancer toward predictive biomarkers and personalized therapies

Objective: Matrix metalloproteinases (MMPs) and Tissue inhibitors of metalloproteinases (TIMPs) are involved in the turnover of extracellular matrix (ECM) components. Overexpression of MMPs facilitates tumour progression by promoting ECM turnover, angiogenesis, and cell migration. Head and neck squa...

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Bibliographic Details
Main Authors: Rishaba Byju, Sredha Sunil, Sabari Sadhasivan, Rajesh Parsanathan
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Oral Oncology Reports
Subjects:
Matrix metalloproteinases
Tissue inhibitors of metalloproteinases
Head and neck cancer
HNSCC
Bioinformatics
Prognostic biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2772906024004291
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