Kinetic modeling of 18F-PI-2620 binding in the brain using an image-derived input function with total-body PET

Kinetic modeling of 18F-PI-2620 binding in the brain using an image-derived input function with total-body PET

Abstract Background Accurate quantification of tau binding from 18F-PI-2620 PET requires kinetic modeling and an input function. We aimed to implement a non-invasive Image-derived input function (IDIF) using the state-of-the-art total-body uEXPLORER PET/CT scanner to quantify tau binding and tracer...

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Bibliographic Details
Main Authors: Anjan Bhattarai, Emily Nicole Holy, Yiran Wang, Benjamin A. Spencer, Guobao Wang, Charles DeCarli, Audrey P. Fan
Format: Article
Language:English
Published: SpringerOpen 2025-05-01
Series:EJNMMI Research
Subjects:
Tau
18F-PI-2620
Kinetic modeling
Grey matter
Image-derived input function
Total-body PET
Online Access:https://doi.org/10.1186/s13550-025-01260-4
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