MicroRNA-221 protects myocardial contractility in myocardial ischemia/reperfusion injury through phospholamban.

MicroRNA-221 protects myocardial contractility in myocardial ischemia/reperfusion injury through phospholamban.

<h4>Objective</h4>To investigate the effects and mechanisms of miRNA 221 on myocardial ischemia/reperfusion injury (MIRI) in mice through the regulation of phospholamban (PLB) expression.<h4>Methods</h4>The MIRI mouse model was created and mice were divided into sham, MIRI, M...

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Bibliographic Details
Main Authors: Hongyu Li, Jimiao Qiu, Chang Liu, Guobing Yu, Danyu Wu, Yichun Chu, Kai Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0316887
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