Predominant white matter microstructural changes over gray matter in tinnitus brain
Introduction: To explore microstructure changes across brain white matter and gray matter in tinnitus patients and its effect on neuropsychological performance. Methods: The cross-sectional study used Multi-shell Diffusion Weighted Imaging data and neuropsychological assessment from 48 tinnitus pati...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925002381 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850188100304633856 |
|---|---|
| author | Qianhui Xu Tingting Chai Jun Yao Chunhua Xing Xiaomin Xu Xindao Yin Fei Zhao Richard Salvi Yu-Chen Chen Yuexin Cai |
| author_facet | Qianhui Xu Tingting Chai Jun Yao Chunhua Xing Xiaomin Xu Xindao Yin Fei Zhao Richard Salvi Yu-Chen Chen Yuexin Cai |
| author_sort | Qianhui Xu |
| collection | DOAJ |
| description | Introduction: To explore microstructure changes across brain white matter and gray matter in tinnitus patients and its effect on neuropsychological performance. Methods: The cross-sectional study used Multi-shell Diffusion Weighted Imaging data and neuropsychological assessment from 48 tinnitus patients and 48 healthy controls. Microstructural features across over white matter and gray matter based on Diffusion Tensor Imaging (DTI) and Neurite Orientation Dispersion and Density Imaging (NODDI) model using Tract-Based Spatial Statistics (TBSS) and Gray Matter-Based Spatial Statistics (GBSS), as well as topological properties were derived from an advanced tractography model in subjects. Brain-neuropsychological performance correlations were analyzed. Results: Tinnitus patients showed decreased axial diffusivity in forceps minor and right corticospinal tract, increased orientation dispersion in forceps minor, decreased connection strength between the right caudate and pericalcarine, right caudate and superior temporal lobe, and left putamen and cuneus. Global network efficiency and local network efficiency were significantly less in tinnitus patients while feeder connection strength was significantly less in tinnitus patients. The orientation dispersion value mediated the relationship between tinnitus status and Trail Making Test–Part B scores. However, no obvious microstructural changes in gray matter were observed. Conclusion: Leveraging multi-shell DWI data, the current study indicated that fiber disruption and internal connectivity organizational changes in brain white matter, rather than gray matter, were more susceptible in tinnitus patients. These microstructural changes in white matter could be associated with changes in cognitive function in tinnitus patients. |
| format | Article |
| id | doaj-art-b0bbb88937134873b20a0aefbe030272 |
| institution | OA Journals |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-b0bbb88937134873b20a0aefbe0302722025-08-20T02:15:58ZengElsevierNeuroImage1095-95722025-05-0131212123510.1016/j.neuroimage.2025.121235Predominant white matter microstructural changes over gray matter in tinnitus brainQianhui Xu0Tingting Chai1Jun Yao2Chunhua Xing3Xiaomin Xu4Xindao Yin5Fei Zhao6Richard Salvi7Yu-Chen Chen8Yuexin Cai9Department of Otolaryngology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Radiology, Nanjing Central Hospital, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Speech and Language Therapy and Hearing Science, Cardiff Metropolitan University, Cardiff, UKCenter for Hearing and Deafness, University at Buffalo, The State University of New York, Buffalo, United StatesDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Corresponding authors.Department of Otolaryngology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Corresponding authors.Introduction: To explore microstructure changes across brain white matter and gray matter in tinnitus patients and its effect on neuropsychological performance. Methods: The cross-sectional study used Multi-shell Diffusion Weighted Imaging data and neuropsychological assessment from 48 tinnitus patients and 48 healthy controls. Microstructural features across over white matter and gray matter based on Diffusion Tensor Imaging (DTI) and Neurite Orientation Dispersion and Density Imaging (NODDI) model using Tract-Based Spatial Statistics (TBSS) and Gray Matter-Based Spatial Statistics (GBSS), as well as topological properties were derived from an advanced tractography model in subjects. Brain-neuropsychological performance correlations were analyzed. Results: Tinnitus patients showed decreased axial diffusivity in forceps minor and right corticospinal tract, increased orientation dispersion in forceps minor, decreased connection strength between the right caudate and pericalcarine, right caudate and superior temporal lobe, and left putamen and cuneus. Global network efficiency and local network efficiency were significantly less in tinnitus patients while feeder connection strength was significantly less in tinnitus patients. The orientation dispersion value mediated the relationship between tinnitus status and Trail Making Test–Part B scores. However, no obvious microstructural changes in gray matter were observed. Conclusion: Leveraging multi-shell DWI data, the current study indicated that fiber disruption and internal connectivity organizational changes in brain white matter, rather than gray matter, were more susceptible in tinnitus patients. These microstructural changes in white matter could be associated with changes in cognitive function in tinnitus patients.http://www.sciencedirect.com/science/article/pii/S1053811925002381TinnitusMulti-shellMicrostructuralTopological propertiesNeuropsychological |
| spellingShingle | Qianhui Xu Tingting Chai Jun Yao Chunhua Xing Xiaomin Xu Xindao Yin Fei Zhao Richard Salvi Yu-Chen Chen Yuexin Cai Predominant white matter microstructural changes over gray matter in tinnitus brain NeuroImage Tinnitus Multi-shell Microstructural Topological properties Neuropsychological |
| title | Predominant white matter microstructural changes over gray matter in tinnitus brain |
| title_full | Predominant white matter microstructural changes over gray matter in tinnitus brain |
| title_fullStr | Predominant white matter microstructural changes over gray matter in tinnitus brain |
| title_full_unstemmed | Predominant white matter microstructural changes over gray matter in tinnitus brain |
| title_short | Predominant white matter microstructural changes over gray matter in tinnitus brain |
| title_sort | predominant white matter microstructural changes over gray matter in tinnitus brain |
| topic | Tinnitus Multi-shell Microstructural Topological properties Neuropsychological |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925002381 |
| work_keys_str_mv | AT qianhuixu predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain AT tingtingchai predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain AT junyao predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain AT chunhuaxing predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain AT xiaominxu predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain AT xindaoyin predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain AT feizhao predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain AT richardsalvi predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain AT yuchenchen predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain AT yuexincai predominantwhitemattermicrostructuralchangesovergraymatterintinnitusbrain |