Macromolecular crystallography and biology at the Linac Coherent Light Source
The Linac Coherent Light Source (LCLS) has significantly impacted the field of biology by providing advanced capabilities for probing the structure and dynamics of biological molecules with high precision. The ultrashort coherent X-ray pulses from the LCLS have enabled ultrafast, time-resolved, seri...
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| Format: | Article |
| Language: | English |
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International Union of Crystallography
2025-05-01
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| Series: | Journal of Synchrotron Radiation |
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| Online Access: | https://journals.iucr.org/paper?S1600577525002735 |
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| author | Sandra Mous Mark S. Hunter Frédéric Poitevin Sébastien Boutet Leland B. Gee |
| author_facet | Sandra Mous Mark S. Hunter Frédéric Poitevin Sébastien Boutet Leland B. Gee |
| author_sort | Sandra Mous |
| collection | DOAJ |
| description | The Linac Coherent Light Source (LCLS) has significantly impacted the field of biology by providing advanced capabilities for probing the structure and dynamics of biological molecules with high precision. The ultrashort coherent X-ray pulses from the LCLS have enabled ultrafast, time-resolved, serial femtosecond crystallography that is inaccessible at conventional synchrotron light sources. Since the facility's founding, scientists have captured detailed insights into biological processes at atomic resolution and fundamental timescales. The ability to observe these processes in real time and under conditions closely resembling their natural state is transforming our approach to studying biochemical mechanisms and developing new medical and energy applications. This work recounts some of the history of the LCLS, advances in biological research enabled by the LCLS, key biological areas that have been impacted and how the LCLS has helped to unravel complex biological phenomena in these fields. |
| format | Article |
| id | doaj-art-b0ba54ef294d49068f6fa1f44f476da3 |
| institution | OA Journals |
| issn | 1600-5775 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | International Union of Crystallography |
| record_format | Article |
| series | Journal of Synchrotron Radiation |
| spelling | doaj-art-b0ba54ef294d49068f6fa1f44f476da32025-08-20T02:28:27ZengInternational Union of CrystallographyJournal of Synchrotron Radiation1600-57752025-05-0132354856610.1107/S1600577525002735he5688Macromolecular crystallography and biology at the Linac Coherent Light SourceSandra Mous0Mark S. Hunter1Frédéric Poitevin2Sébastien Boutet3Leland B. Gee4Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USALinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USALinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USALinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USALinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USAThe Linac Coherent Light Source (LCLS) has significantly impacted the field of biology by providing advanced capabilities for probing the structure and dynamics of biological molecules with high precision. The ultrashort coherent X-ray pulses from the LCLS have enabled ultrafast, time-resolved, serial femtosecond crystallography that is inaccessible at conventional synchrotron light sources. Since the facility's founding, scientists have captured detailed insights into biological processes at atomic resolution and fundamental timescales. The ability to observe these processes in real time and under conditions closely resembling their natural state is transforming our approach to studying biochemical mechanisms and developing new medical and energy applications. This work recounts some of the history of the LCLS, advances in biological research enabled by the LCLS, key biological areas that have been impacted and how the LCLS has helped to unravel complex biological phenomena in these fields.https://journals.iucr.org/paper?S1600577525002735x-ray free-electron lasersserial femtosecond crystallographyprotein crystallographytime-resolved crystallographyroom-temperature crystallography |
| spellingShingle | Sandra Mous Mark S. Hunter Frédéric Poitevin Sébastien Boutet Leland B. Gee Macromolecular crystallography and biology at the Linac Coherent Light Source Journal of Synchrotron Radiation x-ray free-electron lasers serial femtosecond crystallography protein crystallography time-resolved crystallography room-temperature crystallography |
| title | Macromolecular crystallography and biology at the Linac Coherent Light Source |
| title_full | Macromolecular crystallography and biology at the Linac Coherent Light Source |
| title_fullStr | Macromolecular crystallography and biology at the Linac Coherent Light Source |
| title_full_unstemmed | Macromolecular crystallography and biology at the Linac Coherent Light Source |
| title_short | Macromolecular crystallography and biology at the Linac Coherent Light Source |
| title_sort | macromolecular crystallography and biology at the linac coherent light source |
| topic | x-ray free-electron lasers serial femtosecond crystallography protein crystallography time-resolved crystallography room-temperature crystallography |
| url | https://journals.iucr.org/paper?S1600577525002735 |
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