Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico
Introduction: On April 2009, the Mexican Ministry of Health received notification of cases of severe pneumonia mostly affecting young healthy people; this was the beginning of the first influenza pandemic of the 21st century. The nature of the immune response to the influenza A(H1N1)2009 pandemic st...
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The Journal of Infection in Developing Countries
2015-02-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/5052 |
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| author | Guadalupe Miranda-Novales Lourdes Arriaga-Pizano Cristina Herrera-Castillo Rodolfo Pastelin-Palacios Nuriban Valero-Pacheco Marisol Pérez-Toledo Eduardo Ferat-Osorio Fortino Solórzano-Santos Guillermo Vázquez-Rosales Clara Espitia-Pinzón Irma Zamudio-Lugo Abigail Meza-Chávez Paul Klenerman Armando Isibasi Constantino López-Macías |
| author_facet | Guadalupe Miranda-Novales Lourdes Arriaga-Pizano Cristina Herrera-Castillo Rodolfo Pastelin-Palacios Nuriban Valero-Pacheco Marisol Pérez-Toledo Eduardo Ferat-Osorio Fortino Solórzano-Santos Guillermo Vázquez-Rosales Clara Espitia-Pinzón Irma Zamudio-Lugo Abigail Meza-Chávez Paul Klenerman Armando Isibasi Constantino López-Macías |
| author_sort | Guadalupe Miranda-Novales |
| collection | DOAJ |
| description | Introduction: On April 2009, the Mexican Ministry of Health received notification of cases of severe pneumonia mostly affecting young healthy people; this was the beginning of the first influenza pandemic of the 21st century. The nature of the immune response to the influenza A(H1N1)2009 pandemic strain in Mexico at the beginning of the pandemic outbreak has not been completely defined. We describe the serological response to the 2009 pandemic influenza virus in paediatric patients with influenza-like illness, their household contacts (HHCs), and exposed health-care workers (HCWs) at the beginning of the pandemic outbreak in Mexico City.
Methodology: thirty pre-epidemic and 129 epidemic samples were collected and serum antibodies were measured against A(H1N1)2009 pandemic virus and two non-pandemic swine influenza viruses by an haemagglutination inhibition assay .
Results: 91% (29/32) of the convalescence samples from confirmed patients had an antibody titre ≥ 10 (GMT 25), 63% (41/65) of the HHCs (GMT 12), 41% of HCWs (GMT 6) and 13% (4/30) of pre-epidemic samples (GMT 6) for the pandemic influenza virus. Of the 32 confirmed cases, 60% had an antibody titre ≥ 40 for the pandemic strain, 53% for the A/swine/Iowa(H1N1) virus (GMT 62) and 43% for the A/swine/Texas(H3N2) virus (GMT 66).
Conclusion: The antibody response to 2009 pandemic influenza virus was widespread in convalescence samples from patients with confirmed pandemic influenza infection but the GMT was below the protective titre. There was no evidence that antibodies to the swine influenza viruses had cross-protective effect against the 2009 pandemic influenza virus.
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| format | Article |
| id | doaj-art-b0b61e19875a4fce89fbd9b33c74c08d |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-b0b61e19875a4fce89fbd9b33c74c08d2025-08-20T02:27:09ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802015-02-0190310.3855/jidc.5052Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in MexicoGuadalupe Miranda-Novales0Lourdes Arriaga-Pizano1Cristina Herrera-Castillo2Rodolfo Pastelin-Palacios3Nuriban Valero-Pacheco4Marisol Pérez-Toledo5Eduardo Ferat-Osorio6Fortino Solórzano-Santos7Guillermo Vázquez-Rosales8Clara Espitia-Pinzón9Irma Zamudio-Lugo10Abigail Meza-Chávez11Paul Klenerman12Armando Isibasi13Constantino López-Macías14Paediatrics Hospital, National Medical Centre “Siglo XXI”, Mexican Social Security Institute (IMSS), Mexico City, MexicoSpecialties Hospital, National Medical Centre “Siglo XXI” IMSS, Mexico City, MexicoPaediatrics Hospital, National Medical Centre “Siglo XXI”, IMSS, Mexico City, MexicoFacultad de Química, Universidad Nacional Autónoma de México, MexicoSpecialties Hospital, National Medical Centre “Siglo XXI” IMSS, Mexico City, MexicoSpecialties Hospital, National Medical Centre “Siglo XXI” IMSS, Mexico City, MexicoSpecialties Hospital, National Medical Centre “Siglo XXI” IMSS, Mexico City, MexicoPaediatrics Hospital, National Medical Centre “Siglo XXI”, IMSS, Mexico City, MexicoPaediatrics Hospital, National Medical Centre “Siglo XXI”, IMSS, Mexico City, MexicoInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, MexicoPaediatrics Hospital, National Medical Centre “Siglo XXI”, IMSS, Mexico City, MexicoPaediatrics Hospital, National Medical Centre “Siglo XXI”, IMSS, Mexico City, MexicoPeter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomSpecialties Hospital, National Medical Centre “Siglo XXI” IMSS, Mexico City, MexicoSpecialties Hospital, National Medical Centre “Siglo XXI” IMSS, Mexico City, MexicoIntroduction: On April 2009, the Mexican Ministry of Health received notification of cases of severe pneumonia mostly affecting young healthy people; this was the beginning of the first influenza pandemic of the 21st century. The nature of the immune response to the influenza A(H1N1)2009 pandemic strain in Mexico at the beginning of the pandemic outbreak has not been completely defined. We describe the serological response to the 2009 pandemic influenza virus in paediatric patients with influenza-like illness, their household contacts (HHCs), and exposed health-care workers (HCWs) at the beginning of the pandemic outbreak in Mexico City. Methodology: thirty pre-epidemic and 129 epidemic samples were collected and serum antibodies were measured against A(H1N1)2009 pandemic virus and two non-pandemic swine influenza viruses by an haemagglutination inhibition assay . Results: 91% (29/32) of the convalescence samples from confirmed patients had an antibody titre ≥ 10 (GMT 25), 63% (41/65) of the HHCs (GMT 12), 41% of HCWs (GMT 6) and 13% (4/30) of pre-epidemic samples (GMT 6) for the pandemic influenza virus. Of the 32 confirmed cases, 60% had an antibody titre ≥ 40 for the pandemic strain, 53% for the A/swine/Iowa(H1N1) virus (GMT 62) and 43% for the A/swine/Texas(H3N2) virus (GMT 66). Conclusion: The antibody response to 2009 pandemic influenza virus was widespread in convalescence samples from patients with confirmed pandemic influenza infection but the GMT was below the protective titre. There was no evidence that antibodies to the swine influenza viruses had cross-protective effect against the 2009 pandemic influenza virus. https://jidc.org/index.php/journal/article/view/5052Pandemic influenzaH1N1antibody responsehousehold contacthealthcare worker |
| spellingShingle | Guadalupe Miranda-Novales Lourdes Arriaga-Pizano Cristina Herrera-Castillo Rodolfo Pastelin-Palacios Nuriban Valero-Pacheco Marisol Pérez-Toledo Eduardo Ferat-Osorio Fortino Solórzano-Santos Guillermo Vázquez-Rosales Clara Espitia-Pinzón Irma Zamudio-Lugo Abigail Meza-Chávez Paul Klenerman Armando Isibasi Constantino López-Macías Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico Journal of Infection in Developing Countries Pandemic influenza H1N1 antibody response household contact healthcare worker |
| title | Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico |
| title_full | Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico |
| title_fullStr | Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico |
| title_full_unstemmed | Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico |
| title_short | Antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in Mexico |
| title_sort | antibody responses to influenza viruses in paediatric patients and their contacts at the onset of the 2009 pandemic in mexico |
| topic | Pandemic influenza H1N1 antibody response household contact healthcare worker |
| url | https://jidc.org/index.php/journal/article/view/5052 |
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