Association of visceral adiposity index and chronic pain in US adults: a cross-sectional study
Abstract The Visceral Obesity Index (VAI) is utilized as a metric employed to assess the distribution of abdominal adipose tissue as well as the functional status of adipose tissue. Nevertheless, the interplay between VAI and persistent pain has yet to be investigated. This cross-sectional analysis...
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-93041-1 |
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| author | Weilong Xu Ruizhen Shi Youzhuang Zhu Wei Feng |
| author_facet | Weilong Xu Ruizhen Shi Youzhuang Zhu Wei Feng |
| author_sort | Weilong Xu |
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| description | Abstract The Visceral Obesity Index (VAI) is utilized as a metric employed to assess the distribution of abdominal adipose tissue as well as the functional status of adipose tissue. Nevertheless, the interplay between VAI and persistent pain has yet to be investigated. This cross-sectional analysis investigated the relationship between VAI and persistent pain among 1357 American adults from NHANES data. A logarithmic transformation of VAI was performed to adjust for skewness. Following the adjustment for relevant variables, logistic regression analysis showed a noteworthy association between VAI and chronic pain, suggesting that higher VAI values may be linked to an increased prevalence of persistent pain. Curve fitting analysis revealed a nonlinear correlation, with a breakpoint at a VAI value of 0.18. For VAI values below this threshold, each unit increase was notably correlated with an elevated prevalence of persistent pain, while increases in VAI beyond this threshold did not show a significant impact on chronic pain prevalence. Subgroup analyses indicated that the VAI may serve as a relatively independent risk factor for persistent pain. These findings highlight the possibility of incorporating abdominal adipose modification into pain management approaches and emphasize the critical importance of monitoring visceral fat accumulation to better identify patients more susceptible to chronic pain. |
| format | Article |
| id | doaj-art-b0b5a70c58c24196a4b5dbfbfa8f5631 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-b0b5a70c58c24196a4b5dbfbfa8f56312025-08-20T03:41:40ZengNature PortfolioScientific Reports2045-23222025-03-0115111110.1038/s41598-025-93041-1Association of visceral adiposity index and chronic pain in US adults: a cross-sectional studyWeilong Xu0Ruizhen Shi1Youzhuang Zhu2Wei Feng3Department of Anesthesiology, The Affiliated Hospital of Qingdao UniversityQingdao UniversityDepartment of Anesthesiology, The Affiliated Hospital of Qingdao UniversityDepartment of Anesthesiology, The Affiliated Hospital of Qingdao UniversityAbstract The Visceral Obesity Index (VAI) is utilized as a metric employed to assess the distribution of abdominal adipose tissue as well as the functional status of adipose tissue. Nevertheless, the interplay between VAI and persistent pain has yet to be investigated. This cross-sectional analysis investigated the relationship between VAI and persistent pain among 1357 American adults from NHANES data. A logarithmic transformation of VAI was performed to adjust for skewness. Following the adjustment for relevant variables, logistic regression analysis showed a noteworthy association between VAI and chronic pain, suggesting that higher VAI values may be linked to an increased prevalence of persistent pain. Curve fitting analysis revealed a nonlinear correlation, with a breakpoint at a VAI value of 0.18. For VAI values below this threshold, each unit increase was notably correlated with an elevated prevalence of persistent pain, while increases in VAI beyond this threshold did not show a significant impact on chronic pain prevalence. Subgroup analyses indicated that the VAI may serve as a relatively independent risk factor for persistent pain. These findings highlight the possibility of incorporating abdominal adipose modification into pain management approaches and emphasize the critical importance of monitoring visceral fat accumulation to better identify patients more susceptible to chronic pain.https://doi.org/10.1038/s41598-025-93041-1ObesityVisceral adiposity indexPersistent painNHANESPrevalence study |
| spellingShingle | Weilong Xu Ruizhen Shi Youzhuang Zhu Wei Feng Association of visceral adiposity index and chronic pain in US adults: a cross-sectional study Scientific Reports Obesity Visceral adiposity index Persistent pain NHANES Prevalence study |
| title | Association of visceral adiposity index and chronic pain in US adults: a cross-sectional study |
| title_full | Association of visceral adiposity index and chronic pain in US adults: a cross-sectional study |
| title_fullStr | Association of visceral adiposity index and chronic pain in US adults: a cross-sectional study |
| title_full_unstemmed | Association of visceral adiposity index and chronic pain in US adults: a cross-sectional study |
| title_short | Association of visceral adiposity index and chronic pain in US adults: a cross-sectional study |
| title_sort | association of visceral adiposity index and chronic pain in us adults a cross sectional study |
| topic | Obesity Visceral adiposity index Persistent pain NHANES Prevalence study |
| url | https://doi.org/10.1038/s41598-025-93041-1 |
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