Real-life evaluation of incidence and clinical outcomes of COVID-19 among healthcare workers during pre-vaccination and post-vaccination periods: A cross-sectional impact study
Introduction: We aimed to evaluate the prevalence and clinical outcomes of COVID-19 in healthcare workers (HCWs) in the pre-vaccination and post-vaccination periods. In addition, we determined factors associated with the development of COVID-19 after vaccination. Methodology: In this analytical c...
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The Journal of Infection in Developing Countries
2023-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/17206 |
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| author | Yusuf Emre Ozdemir Aysegul Inci Sezen Serkan Surme Sevtap Senoglu Zuhal Yesilbag Meryem Sahin Ozdemir Osman Faruk Bayramlar Emine Ilay Duman Nomin Bold Habip Gedik Kadriye Kart Yasar |
| author_facet | Yusuf Emre Ozdemir Aysegul Inci Sezen Serkan Surme Sevtap Senoglu Zuhal Yesilbag Meryem Sahin Ozdemir Osman Faruk Bayramlar Emine Ilay Duman Nomin Bold Habip Gedik Kadriye Kart Yasar |
| author_sort | Yusuf Emre Ozdemir |
| collection | DOAJ |
| description |
Introduction: We aimed to evaluate the prevalence and clinical outcomes of COVID-19 in healthcare workers (HCWs) in the pre-vaccination and post-vaccination periods. In addition, we determined factors associated with the development of COVID-19 after vaccination.
Methodology: In this analytical cross-sectional epidemiological study, HCWs who were vaccinated between January 14, 2021, and March 21, 2021, were included. HCWs were followed up for 105 days after the 2 doses of CoronaVac. Pre-vaccination and post-vaccination periods were compared.
Results: A total of 1,000 HCWs were included, 576 patients (57.6%) were male, and the mean age was 33.2 ± 9.6 years. In the last 3 months during the pre-vaccination period, 187 patients had COVID-19, and the cumulative incidence of COVID-19 was 18.7%. Six of these patients were hospitalized. Severe disease was observed in three patients. In the first 3 months post-vaccination period, COVID-19 was detected in 50 patients, and the cumulative incidence of the disease was determined to be 6.1%. Hospitalization and severe disease were not detected. Age (p = 0.29), sex (OR = 1.5, p = 0.16), smoking (OR = 1.29, p = 0.43), and underlying diseases (OR = 1.6, p = 0.26) were not associated with post-vaccination COVID-19. A history of COVID-19 significantly reduced the likelihood of the development of post-vaccination COVID-19 in multivariate analysis (p = 0.002, OR = 0.16, 95% CI = 0.05-0.51).
Conclusions: CoronaVac significantly reduces the risk of SARS-CoV-2 infection and alleviates the severity of COVID-19 in the early period. Additionally, HCWs who have been infected and vaccinated with CoronaVac are less likely to be reinfected with COVID-19.
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| format | Article |
| id | doaj-art-b0b44b3698b54fcf919abd7c8fc4c6ac |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-b0b44b3698b54fcf919abd7c8fc4c6ac2025-08-20T02:57:04ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802023-03-01170310.3855/jidc.17206Real-life evaluation of incidence and clinical outcomes of COVID-19 among healthcare workers during pre-vaccination and post-vaccination periods: A cross-sectional impact studyYusuf Emre Ozdemir0Aysegul Inci Sezen1Serkan Surme2Sevtap Senoglu3Zuhal Yesilbag4Meryem Sahin Ozdemir5Osman Faruk Bayramlar6Emine Ilay Duman7Nomin Bold8Habip Gedik9Kadriye Kart Yasar10Department of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Haseki Training and Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, TurkeyDepartment of Public Health, Bakirkoy District Health Directorate, Bakirkoy, Istanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training Research Hospital, Istanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training Research Hospital, Istanbul, Turkey Introduction: We aimed to evaluate the prevalence and clinical outcomes of COVID-19 in healthcare workers (HCWs) in the pre-vaccination and post-vaccination periods. In addition, we determined factors associated with the development of COVID-19 after vaccination. Methodology: In this analytical cross-sectional epidemiological study, HCWs who were vaccinated between January 14, 2021, and March 21, 2021, were included. HCWs were followed up for 105 days after the 2 doses of CoronaVac. Pre-vaccination and post-vaccination periods were compared. Results: A total of 1,000 HCWs were included, 576 patients (57.6%) were male, and the mean age was 33.2 ± 9.6 years. In the last 3 months during the pre-vaccination period, 187 patients had COVID-19, and the cumulative incidence of COVID-19 was 18.7%. Six of these patients were hospitalized. Severe disease was observed in three patients. In the first 3 months post-vaccination period, COVID-19 was detected in 50 patients, and the cumulative incidence of the disease was determined to be 6.1%. Hospitalization and severe disease were not detected. Age (p = 0.29), sex (OR = 1.5, p = 0.16), smoking (OR = 1.29, p = 0.43), and underlying diseases (OR = 1.6, p = 0.26) were not associated with post-vaccination COVID-19. A history of COVID-19 significantly reduced the likelihood of the development of post-vaccination COVID-19 in multivariate analysis (p = 0.002, OR = 0.16, 95% CI = 0.05-0.51). Conclusions: CoronaVac significantly reduces the risk of SARS-CoV-2 infection and alleviates the severity of COVID-19 in the early period. Additionally, HCWs who have been infected and vaccinated with CoronaVac are less likely to be reinfected with COVID-19. https://jidc.org/index.php/journal/article/view/17206COVID-19CoronaVachealthcare workers |
| spellingShingle | Yusuf Emre Ozdemir Aysegul Inci Sezen Serkan Surme Sevtap Senoglu Zuhal Yesilbag Meryem Sahin Ozdemir Osman Faruk Bayramlar Emine Ilay Duman Nomin Bold Habip Gedik Kadriye Kart Yasar Real-life evaluation of incidence and clinical outcomes of COVID-19 among healthcare workers during pre-vaccination and post-vaccination periods: A cross-sectional impact study Journal of Infection in Developing Countries COVID-19 CoronaVac healthcare workers |
| title | Real-life evaluation of incidence and clinical outcomes of COVID-19 among healthcare workers during pre-vaccination and post-vaccination periods: A cross-sectional impact study |
| title_full | Real-life evaluation of incidence and clinical outcomes of COVID-19 among healthcare workers during pre-vaccination and post-vaccination periods: A cross-sectional impact study |
| title_fullStr | Real-life evaluation of incidence and clinical outcomes of COVID-19 among healthcare workers during pre-vaccination and post-vaccination periods: A cross-sectional impact study |
| title_full_unstemmed | Real-life evaluation of incidence and clinical outcomes of COVID-19 among healthcare workers during pre-vaccination and post-vaccination periods: A cross-sectional impact study |
| title_short | Real-life evaluation of incidence and clinical outcomes of COVID-19 among healthcare workers during pre-vaccination and post-vaccination periods: A cross-sectional impact study |
| title_sort | real life evaluation of incidence and clinical outcomes of covid 19 among healthcare workers during pre vaccination and post vaccination periods a cross sectional impact study |
| topic | COVID-19 CoronaVac healthcare workers |
| url | https://jidc.org/index.php/journal/article/view/17206 |
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