Gut microbiota and Parkinson’s disease
Abstract. Emerging evidence suggests that dysbiosis of the gut microbiota is associated with the pathogenesis of Parkinson’s disease (PD), a prevalent neurodegenerative disorder. The microbiota–gut–brain axis plays a crucial role in the development and progression of PD, and numerous studies have de...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2025-02-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003318 |
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| author | Lin Wang Ying Cui Bingyu Han Yitong Du Kenish Sirajbhai Salewala Shiya Wang Wenlu Zhao Hongxin Zhang Sichen Wang Xinran Xu Jianpeng Ma Yan Zhu Houzhen Tuo Ting Gao |
| author_facet | Lin Wang Ying Cui Bingyu Han Yitong Du Kenish Sirajbhai Salewala Shiya Wang Wenlu Zhao Hongxin Zhang Sichen Wang Xinran Xu Jianpeng Ma Yan Zhu Houzhen Tuo Ting Gao |
| author_sort | Lin Wang |
| collection | DOAJ |
| description | Abstract. Emerging evidence suggests that dysbiosis of the gut microbiota is associated with the pathogenesis of Parkinson’s disease (PD), a prevalent neurodegenerative disorder. The microbiota–gut–brain axis plays a crucial role in the development and progression of PD, and numerous studies have demonstrated the potential therapeutic benefits of modulations in the intestinal microbiota. This review provides insights into the characterization of the gut microbiota in patients with PD and highlights associations with clinical symptoms and underlying mechanisms. The discussion underscores the increased influence of the gut microbiota in the pathogenesis of PD. While the relationship is not fully elucidated, existing research demonstrates a strong correlation between changes in the composition of gut microbiota and disease development, and further investigation is warranted to explain the specific underlying mechanisms. |
| format | Article |
| id | doaj-art-b0b285a2f9314e938fdf33ea8d80959f |
| institution | Kabale University |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-b0b285a2f9314e938fdf33ea8d80959f2025-01-27T06:04:15ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-02-01138328929710.1097/CM9.0000000000003318202502050-00006Gut microbiota and Parkinson’s diseaseLin Wang0Ying Cui1Bingyu Han2Yitong Du3Kenish Sirajbhai Salewala4Shiya Wang5Wenlu Zhao6Hongxin Zhang7Sichen Wang8Xinran Xu9Jianpeng Ma10Yan Zhu11Houzhen Tuo12Ting Gao1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China2 International School, Capital Medical University, Beijing 100069, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China1 Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract. Emerging evidence suggests that dysbiosis of the gut microbiota is associated with the pathogenesis of Parkinson’s disease (PD), a prevalent neurodegenerative disorder. The microbiota–gut–brain axis plays a crucial role in the development and progression of PD, and numerous studies have demonstrated the potential therapeutic benefits of modulations in the intestinal microbiota. This review provides insights into the characterization of the gut microbiota in patients with PD and highlights associations with clinical symptoms and underlying mechanisms. The discussion underscores the increased influence of the gut microbiota in the pathogenesis of PD. While the relationship is not fully elucidated, existing research demonstrates a strong correlation between changes in the composition of gut microbiota and disease development, and further investigation is warranted to explain the specific underlying mechanisms.http://journals.lww.com/10.1097/CM9.0000000000003318 |
| spellingShingle | Lin Wang Ying Cui Bingyu Han Yitong Du Kenish Sirajbhai Salewala Shiya Wang Wenlu Zhao Hongxin Zhang Sichen Wang Xinran Xu Jianpeng Ma Yan Zhu Houzhen Tuo Ting Gao Gut microbiota and Parkinson’s disease Chinese Medical Journal |
| title | Gut microbiota and Parkinson’s disease |
| title_full | Gut microbiota and Parkinson’s disease |
| title_fullStr | Gut microbiota and Parkinson’s disease |
| title_full_unstemmed | Gut microbiota and Parkinson’s disease |
| title_short | Gut microbiota and Parkinson’s disease |
| title_sort | gut microbiota and parkinson s disease |
| url | http://journals.lww.com/10.1097/CM9.0000000000003318 |
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