Aging-associated sensory decline and Alzheimer’s disease
Abstract Multisensory decline is common as people age, and aging is the primary risk of Alzheimer’s Disease (AD). Recent studies have begun to shed light on the possibility that age-related sensory decline could accelerate AD pathogenesis, or be a prodromal indicator of AD. Sensory impairments, spec...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Molecular Neurodegeneration |
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| Online Access: | https://doi.org/10.1186/s13024-024-00776-y |
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| author | Suji Hong Seung-Hyun Baek Mitchell K. P. Lai Thiruma V. Arumugam Dong-Gyu Jo |
| author_facet | Suji Hong Seung-Hyun Baek Mitchell K. P. Lai Thiruma V. Arumugam Dong-Gyu Jo |
| author_sort | Suji Hong |
| collection | DOAJ |
| description | Abstract Multisensory decline is common as people age, and aging is the primary risk of Alzheimer’s Disease (AD). Recent studies have begun to shed light on the possibility that age-related sensory decline could accelerate AD pathogenesis, or be a prodromal indicator of AD. Sensory impairments, specifically in taste and smell, often emerge before cognitive symptoms in AD, indicating their potential as early biomarkers. Olfactory dysfunction has been frequently associated with AD and may offer valuable insights into early detection. Hearing impairment is significantly associated with AD, but its causal impact on AD progression remains unclear. The review also discusses visual and tactile deficits in AD, including retinal thinning and changes in tactile perception, highlighting their links to disease progression. Focusing on molecular mechanisms, the review explores the roles of amyloid-β (Aβ) accumulation and tau protein pathology in sensory decline and their bidirectional relationship with AD. In summary, the evidence presented conclusively supports advocating for an integrated approach to understanding AD and sensory decline, to enhance early detection, implementing preventive strategies, and developing therapeutic interventions for AD. This approach underscores the significance of sensory health in addressing neurodegenerative diseases, particularly AD. |
| format | Article |
| id | doaj-art-b0aa63b169ec46e9bc6a7c6135bc2271 |
| institution | Kabale University |
| issn | 1750-1326 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj-art-b0aa63b169ec46e9bc6a7c6135bc22712025-01-19T12:38:42ZengBMCMolecular Neurodegeneration1750-13262024-12-0119112810.1186/s13024-024-00776-yAging-associated sensory decline and Alzheimer’s diseaseSuji Hong0Seung-Hyun Baek1Mitchell K. P. Lai2Thiruma V. Arumugam3Dong-Gyu Jo4The School of Pharmacy, Sungkyunkwan UniversityThe School of Pharmacy, Sungkyunkwan UniversityDepartment of Pharmacology, Yong Loo Lin School of MedicineThe School of Pharmacy, Sungkyunkwan UniversityThe School of Pharmacy, Sungkyunkwan UniversityAbstract Multisensory decline is common as people age, and aging is the primary risk of Alzheimer’s Disease (AD). Recent studies have begun to shed light on the possibility that age-related sensory decline could accelerate AD pathogenesis, or be a prodromal indicator of AD. Sensory impairments, specifically in taste and smell, often emerge before cognitive symptoms in AD, indicating their potential as early biomarkers. Olfactory dysfunction has been frequently associated with AD and may offer valuable insights into early detection. Hearing impairment is significantly associated with AD, but its causal impact on AD progression remains unclear. The review also discusses visual and tactile deficits in AD, including retinal thinning and changes in tactile perception, highlighting their links to disease progression. Focusing on molecular mechanisms, the review explores the roles of amyloid-β (Aβ) accumulation and tau protein pathology in sensory decline and their bidirectional relationship with AD. In summary, the evidence presented conclusively supports advocating for an integrated approach to understanding AD and sensory decline, to enhance early detection, implementing preventive strategies, and developing therapeutic interventions for AD. This approach underscores the significance of sensory health in addressing neurodegenerative diseases, particularly AD.https://doi.org/10.1186/s13024-024-00776-yAlzheimer's Disease (AD)AgingSensory impairmentsEarly biomarkers |
| spellingShingle | Suji Hong Seung-Hyun Baek Mitchell K. P. Lai Thiruma V. Arumugam Dong-Gyu Jo Aging-associated sensory decline and Alzheimer’s disease Molecular Neurodegeneration Alzheimer's Disease (AD) Aging Sensory impairments Early biomarkers |
| title | Aging-associated sensory decline and Alzheimer’s disease |
| title_full | Aging-associated sensory decline and Alzheimer’s disease |
| title_fullStr | Aging-associated sensory decline and Alzheimer’s disease |
| title_full_unstemmed | Aging-associated sensory decline and Alzheimer’s disease |
| title_short | Aging-associated sensory decline and Alzheimer’s disease |
| title_sort | aging associated sensory decline and alzheimer s disease |
| topic | Alzheimer's Disease (AD) Aging Sensory impairments Early biomarkers |
| url | https://doi.org/10.1186/s13024-024-00776-y |
| work_keys_str_mv | AT sujihong agingassociatedsensorydeclineandalzheimersdisease AT seunghyunbaek agingassociatedsensorydeclineandalzheimersdisease AT mitchellkplai agingassociatedsensorydeclineandalzheimersdisease AT thirumavarumugam agingassociatedsensorydeclineandalzheimersdisease AT donggyujo agingassociatedsensorydeclineandalzheimersdisease |