Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients
Introduction Intermittent hypoxaemia is closely associated with cardiovascular dysfunction and may be a more accurate indicator of obstructive sleep apnoea (OSA) severity than conventional metrics. Another key factor is the lung-to-finger circulation time (LFCt), defined as the duration from the ces...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-07-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/4/01051-2023.full |
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| author | Purbanka Pahari Henri Korkalainen Erna Sif Arnardóttir Anna Sigridur Islind Elias August Arie Oksenberg Juha Töyräs Timo Leppänen Sami Nikkonen |
| author_facet | Purbanka Pahari Henri Korkalainen Erna Sif Arnardóttir Anna Sigridur Islind Elias August Arie Oksenberg Juha Töyräs Timo Leppänen Sami Nikkonen |
| author_sort | Purbanka Pahari |
| collection | DOAJ |
| description | Introduction
Intermittent hypoxaemia is closely associated with cardiovascular dysfunction and may be a more accurate indicator of obstructive sleep apnoea (OSA) severity than conventional metrics. Another key factor is the lung-to-finger circulation time (LFCt), defined as the duration from the cessation of a respiratory event to the lowest point of oxygen desaturation. LFCt serves as a surrogate marker for circulatory delay and is linked with cardiovascular function. Yet, the specific associations between respiratory and hypoxaemia characteristics and LFCt in patients with OSA remain unclear. This study aims to investigate these associations, ultimately contributing to a more nuanced understanding of OSA severity.
Methods
The study comprised 878 in-lab polysomnographies of patients with suspected OSA. The conventional OSA metrics were computed along with nine hypoxaemia metrics and then divided into quartiles (Q1–Q4) based on respiratory event duration. In addition, these were further divided into subquartiles based on LFCt. The empirical cumulative distribution functions (CDFs) and linear regression models were used to investigate the association between desaturation metrics and LFCt.
Results
The results showed that prolonged LFCt was associated with increased hypoxic severity. Based on CDFs, the hypoxic severity significantly increased with longer LFCt despite the duration of respiratory events. Furthermore, fall duration was elevated in patients with longer LFCt (Q1- desaturation fall duration (FallDur): 14.6 s; Q4-FallDur: 29.8 s; p<0.0001). The regression models also showed significant association between hypoxic severity and LFCt (Q1-desaturation fall slope (FallSlope): β=−3.224; Q4-FallSlope: β=−6.178; p<0.0001).
Discussion
Considering LFCt along with desaturation metrics might be useful in estimating the association between the severity of OSA, physiological consequences of respiratory events and cardiac health. |
| format | Article |
| id | doaj-art-b0a7c32fabf943dab8d1617d543e6e35 |
| institution | OA Journals |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-b0a7c32fabf943dab8d1617d543e6e352025-08-20T01:54:25ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-07-0110410.1183/23120541.01051-202301051-2023Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patientsPurbanka Pahari0Henri Korkalainen1Erna Sif Arnardóttir2Anna Sigridur Islind3Elias August4Arie Oksenberg5Juha Töyräs6Timo Leppänen7Sami Nikkonen8 Department of Technical Physics, University of Eastern Finland, Kuopio, Finland Department of Technical Physics, University of Eastern Finland, Kuopio, Finland Reykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland Reykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland Reykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland Sleep Disorders Unit, Loewenstein Hospital Rehabilitation Center, Raanana, Israel Department of Technical Physics, University of Eastern Finland, Kuopio, Finland Department of Technical Physics, University of Eastern Finland, Kuopio, Finland Department of Technical Physics, University of Eastern Finland, Kuopio, Finland Introduction Intermittent hypoxaemia is closely associated with cardiovascular dysfunction and may be a more accurate indicator of obstructive sleep apnoea (OSA) severity than conventional metrics. Another key factor is the lung-to-finger circulation time (LFCt), defined as the duration from the cessation of a respiratory event to the lowest point of oxygen desaturation. LFCt serves as a surrogate marker for circulatory delay and is linked with cardiovascular function. Yet, the specific associations between respiratory and hypoxaemia characteristics and LFCt in patients with OSA remain unclear. This study aims to investigate these associations, ultimately contributing to a more nuanced understanding of OSA severity. Methods The study comprised 878 in-lab polysomnographies of patients with suspected OSA. The conventional OSA metrics were computed along with nine hypoxaemia metrics and then divided into quartiles (Q1–Q4) based on respiratory event duration. In addition, these were further divided into subquartiles based on LFCt. The empirical cumulative distribution functions (CDFs) and linear regression models were used to investigate the association between desaturation metrics and LFCt. Results The results showed that prolonged LFCt was associated with increased hypoxic severity. Based on CDFs, the hypoxic severity significantly increased with longer LFCt despite the duration of respiratory events. Furthermore, fall duration was elevated in patients with longer LFCt (Q1- desaturation fall duration (FallDur): 14.6 s; Q4-FallDur: 29.8 s; p<0.0001). The regression models also showed significant association between hypoxic severity and LFCt (Q1-desaturation fall slope (FallSlope): β=−3.224; Q4-FallSlope: β=−6.178; p<0.0001). Discussion Considering LFCt along with desaturation metrics might be useful in estimating the association between the severity of OSA, physiological consequences of respiratory events and cardiac health.http://openres.ersjournals.com/content/10/4/01051-2023.full |
| spellingShingle | Purbanka Pahari Henri Korkalainen Erna Sif Arnardóttir Anna Sigridur Islind Elias August Arie Oksenberg Juha Töyräs Timo Leppänen Sami Nikkonen Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients ERJ Open Research |
| title | Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients |
| title_full | Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients |
| title_fullStr | Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients |
| title_full_unstemmed | Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients |
| title_short | Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients |
| title_sort | prolonged lung to finger circulation time indicates an increased risk of intermittent hypoxaemia in sleep apnoea patients |
| url | http://openres.ersjournals.com/content/10/4/01051-2023.full |
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