Leptin, Adiponectin, and Obesity among Caucasian and Asian Women
Ethnic differences in adipose tissue distribution may contribute to different chronic disease risks across ethnic groups, and adipokines may mediate the risk. In a cross-sectional study, we examined ethnic differences in adipokines and inflammatory markers as related to body mass index (BMI) among 1...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2011/253580 |
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| author | Shannon M. Conroy Weiwen Chai Unhee Lim Adrian A. Franke Robert V. Cooney Gertraud Maskarinec |
| author_facet | Shannon M. Conroy Weiwen Chai Unhee Lim Adrian A. Franke Robert V. Cooney Gertraud Maskarinec |
| author_sort | Shannon M. Conroy |
| collection | DOAJ |
| description | Ethnic differences in adipose tissue distribution may contribute to different chronic disease risks across ethnic groups, and adipokines may mediate the risk. In a cross-sectional study, we examined ethnic differences in adipokines and inflammatory markers as related to body mass index (BMI) among 183 premenopausal women with Caucasian and Asian ancestry. General linear models were used to estimate adjusted mean levels of leptin, adiponectin, interleukin-6, and C-reactive protein (CRP). Asian women had significantly lower serum levels of leptin, adiponectin, and CRP than Caucasian participants (P≤.01) across all levels of BMI. Among overweight and obese women, Asians showed a stronger association of CRP with leptin (β=1.34 versus β=0.64) and with adiponectin (β=−0.95 versus β=−0.75) than Caucasians. Compared to Caucasians of similar BMI, Asians may experience a higher chronic disease risk due to lower levels of adiponectin despite their lower levels of leptin. |
| format | Article |
| id | doaj-art-b0a4ff5080ee496094bcac98ef95075e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b0a4ff5080ee496094bcac98ef95075e2025-02-03T01:09:48ZengWileyMediators of Inflammation0962-93511466-18612011-01-01201110.1155/2011/253580253580Leptin, Adiponectin, and Obesity among Caucasian and Asian WomenShannon M. Conroy0Weiwen Chai1Unhee Lim2Adrian A. Franke3Robert V. Cooney4Gertraud Maskarinec5University of Hawaii Cancer Center, Cancer Epidemiology Program, Honolulu, HI 96813, USAUniversity of Hawaii Cancer Center, Cancer Epidemiology Program, Honolulu, HI 96813, USAUniversity of Hawaii Cancer Center, Cancer Epidemiology Program, Honolulu, HI 96813, USAUniversity of Hawaii Cancer Center, Cancer Epidemiology Program, Honolulu, HI 96813, USAUniversity of Hawaii Cancer Center, Cancer Epidemiology Program, Honolulu, HI 96813, USAUniversity of Hawaii Cancer Center, Cancer Epidemiology Program, Honolulu, HI 96813, USAEthnic differences in adipose tissue distribution may contribute to different chronic disease risks across ethnic groups, and adipokines may mediate the risk. In a cross-sectional study, we examined ethnic differences in adipokines and inflammatory markers as related to body mass index (BMI) among 183 premenopausal women with Caucasian and Asian ancestry. General linear models were used to estimate adjusted mean levels of leptin, adiponectin, interleukin-6, and C-reactive protein (CRP). Asian women had significantly lower serum levels of leptin, adiponectin, and CRP than Caucasian participants (P≤.01) across all levels of BMI. Among overweight and obese women, Asians showed a stronger association of CRP with leptin (β=1.34 versus β=0.64) and with adiponectin (β=−0.95 versus β=−0.75) than Caucasians. Compared to Caucasians of similar BMI, Asians may experience a higher chronic disease risk due to lower levels of adiponectin despite their lower levels of leptin.http://dx.doi.org/10.1155/2011/253580 |
| spellingShingle | Shannon M. Conroy Weiwen Chai Unhee Lim Adrian A. Franke Robert V. Cooney Gertraud Maskarinec Leptin, Adiponectin, and Obesity among Caucasian and Asian Women Mediators of Inflammation |
| title | Leptin, Adiponectin, and Obesity among Caucasian and Asian Women |
| title_full | Leptin, Adiponectin, and Obesity among Caucasian and Asian Women |
| title_fullStr | Leptin, Adiponectin, and Obesity among Caucasian and Asian Women |
| title_full_unstemmed | Leptin, Adiponectin, and Obesity among Caucasian and Asian Women |
| title_short | Leptin, Adiponectin, and Obesity among Caucasian and Asian Women |
| title_sort | leptin adiponectin and obesity among caucasian and asian women |
| url | http://dx.doi.org/10.1155/2011/253580 |
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