The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model
Respiratory syncytial virus (RSV) is a common cause of severe lower respiratory tract diseases (bronchiolitis and pneumonia) during infancy and early childhood. There is increasing evidence which indicates that severe pulmonary disease caused by RSV infection in infancy is associated with recurrent...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/748038 |
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| author | Junyan Han Katsuyuki Takeda Erwin W. Gelfand |
| author_facet | Junyan Han Katsuyuki Takeda Erwin W. Gelfand |
| author_sort | Junyan Han |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) is a common cause of severe lower respiratory tract diseases (bronchiolitis and pneumonia) during infancy and early childhood. There is increasing evidence which indicates that severe pulmonary disease caused by RSV infection in infancy is associated with recurrent wheezing and development of asthma later in childhood. However, the underlying mechanisms linking RSV infection to persistent airway hyperresponsiveness and dysfunction are not fully defined. To study these processes in ways which are not available in humans, animal models have been established and have provided valuable insight into the pathophysiology of RSV-induced disease. In this paper, we discuss experimental models of RSV infection in mice and highlight a new investigative approach in which mice are initially infected as neonates and then reinfected later in life. The findings shed light on the mechanisms underlying the association between early severe RSV infection and development of asthma later in childhood. |
| format | Article |
| id | doaj-art-b0a45fc8c5dd4d9d9d54822876feea58 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-b0a45fc8c5dd4d9d9d54822876feea582025-02-03T00:59:31ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/748038748038The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse ModelJunyan Han0Katsuyuki Takeda1Erwin W. Gelfand2Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USADivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USADivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USARespiratory syncytial virus (RSV) is a common cause of severe lower respiratory tract diseases (bronchiolitis and pneumonia) during infancy and early childhood. There is increasing evidence which indicates that severe pulmonary disease caused by RSV infection in infancy is associated with recurrent wheezing and development of asthma later in childhood. However, the underlying mechanisms linking RSV infection to persistent airway hyperresponsiveness and dysfunction are not fully defined. To study these processes in ways which are not available in humans, animal models have been established and have provided valuable insight into the pathophysiology of RSV-induced disease. In this paper, we discuss experimental models of RSV infection in mice and highlight a new investigative approach in which mice are initially infected as neonates and then reinfected later in life. The findings shed light on the mechanisms underlying the association between early severe RSV infection and development of asthma later in childhood.http://dx.doi.org/10.1155/2011/748038 |
| spellingShingle | Junyan Han Katsuyuki Takeda Erwin W. Gelfand The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model Pulmonary Medicine |
| title | The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model |
| title_full | The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model |
| title_fullStr | The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model |
| title_full_unstemmed | The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model |
| title_short | The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model |
| title_sort | role of rsv infection in asthma initiation and progression findings in a mouse model |
| url | http://dx.doi.org/10.1155/2011/748038 |
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