Differential MYC Phosphorylation Drives the Divergent Cholangiocyte Response to StressSummary

Differential MYC Phosphorylation Drives the Divergent Cholangiocyte Response to StressSummary

Background & Aims: In primary sclerosing cholangitis (PSC), some cholangiocytes undergo cell cycle arrest (senescence), whereas others proliferate (ductular reaction). Our aim was to determine the mechanisms driving this divergent response. Methods: We analyzed PSC and control liver tissue b...

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Bibliographic Details
Main Authors: Steven P. O’Hara, Patrick L. Splinter, Antonia Felzen, Carys A. Turner, Olivia T. Morgenthaler, Gregory J. Gores, Nicholas F. LaRusso
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Ductular Reaction
Primary Sclerosing Cholangitis
Proliferation
Senescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X25000888
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