Oxidative Protein-Folding Systems in Plant Cells
Plants are unique among eukaryotes in having evolved organelles: the protein storage vacuole, protein body, and chloroplast. Disulfide transfer pathways that function in the endoplasmic reticulum (ER) and chloroplasts of plants play critical roles in the development of protein storage organelles and...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2013/585431 |
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| _version_ | 1850176238865350656 |
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| author | Yayoi Onda |
| author_facet | Yayoi Onda |
| author_sort | Yayoi Onda |
| collection | DOAJ |
| description | Plants are unique among eukaryotes in having evolved organelles: the protein storage vacuole, protein body, and chloroplast. Disulfide transfer pathways that function in the endoplasmic reticulum (ER) and chloroplasts of plants play critical roles in the development of protein storage organelles and the biogenesis of chloroplasts, respectively. Disulfide bond formation requires the cooperative function of disulfide-generating enzymes (e.g., ER oxidoreductase 1), which generate disulfide bonds de novo, and disulfide carrier proteins (e.g., protein disulfide isomerase), which transfer disulfides to substrates by means of thiol-disulfide exchange reactions. Selective molecular communication between disulfide-generating enzymes and disulfide carrier proteins, which reflects the molecular and structural diversity of disulfide carrier proteins, is key to the efficient transfer of disulfides to specific sets of substrates. This review focuses on recent advances in our understanding of the mechanisms and functions of the various disulfide transfer pathways involved in oxidative protein folding in the ER, chloroplasts, and mitochondria of plants. |
| format | Article |
| id | doaj-art-b09a5bfdd4e344d0a12460824f2abca2 |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-b09a5bfdd4e344d0a12460824f2abca22025-08-20T02:19:18ZengWileyInternational Journal of Cell Biology1687-88761687-88842013-01-01201310.1155/2013/585431585431Oxidative Protein-Folding Systems in Plant CellsYayoi Onda0Department of Food and Applied Life Sciences, Yamagata University, Yamagata 997-8555, JapanPlants are unique among eukaryotes in having evolved organelles: the protein storage vacuole, protein body, and chloroplast. Disulfide transfer pathways that function in the endoplasmic reticulum (ER) and chloroplasts of plants play critical roles in the development of protein storage organelles and the biogenesis of chloroplasts, respectively. Disulfide bond formation requires the cooperative function of disulfide-generating enzymes (e.g., ER oxidoreductase 1), which generate disulfide bonds de novo, and disulfide carrier proteins (e.g., protein disulfide isomerase), which transfer disulfides to substrates by means of thiol-disulfide exchange reactions. Selective molecular communication between disulfide-generating enzymes and disulfide carrier proteins, which reflects the molecular and structural diversity of disulfide carrier proteins, is key to the efficient transfer of disulfides to specific sets of substrates. This review focuses on recent advances in our understanding of the mechanisms and functions of the various disulfide transfer pathways involved in oxidative protein folding in the ER, chloroplasts, and mitochondria of plants.http://dx.doi.org/10.1155/2013/585431 |
| spellingShingle | Yayoi Onda Oxidative Protein-Folding Systems in Plant Cells International Journal of Cell Biology |
| title | Oxidative Protein-Folding Systems in Plant Cells |
| title_full | Oxidative Protein-Folding Systems in Plant Cells |
| title_fullStr | Oxidative Protein-Folding Systems in Plant Cells |
| title_full_unstemmed | Oxidative Protein-Folding Systems in Plant Cells |
| title_short | Oxidative Protein-Folding Systems in Plant Cells |
| title_sort | oxidative protein folding systems in plant cells |
| url | http://dx.doi.org/10.1155/2013/585431 |
| work_keys_str_mv | AT yayoionda oxidativeproteinfoldingsystemsinplantcells |