Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP Levels
Background: NT-proBNP levels with a wide range at admission play both a diagnostic and a prognostic role in patients with HF. The differences regarding the clinical profiles and demography in decompensated HF patients according to NT-proBNP levels at admission are not clear. Methods: This study aime...
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2024-11-01
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| author | Ruxandra Maria Christodorescu Daniel Miron Brie Alina Diduța Brie Samuel Nistor Alexandru Tîrziu Angela Dragomir Cristian Mornoș Simona Drăgan Daniel Duda-Seiman Adina Pop-Moldovan Dan Dărăbanțiu |
| author_facet | Ruxandra Maria Christodorescu Daniel Miron Brie Alina Diduța Brie Samuel Nistor Alexandru Tîrziu Angela Dragomir Cristian Mornoș Simona Drăgan Daniel Duda-Seiman Adina Pop-Moldovan Dan Dărăbanțiu |
| author_sort | Ruxandra Maria Christodorescu |
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| description | Background: NT-proBNP levels with a wide range at admission play both a diagnostic and a prognostic role in patients with HF. The differences regarding the clinical profiles and demography in decompensated HF patients according to NT-proBNP levels at admission are not clear. Methods: This study aimed to analyze and compare clinical profiles and demographics in patients hospitalized for decompensated heart failure according to levels of NT-proBNP at admission. The study included 302 patients hospitalized for decompensated HF who were divided into three groups based on admission NT-proBNP levels: group A (n = 46, with NT-proBNP level < 3000 pg/mL), group B (n = 130, NT-proBNP level between 3000–10,000 pg/mL), and group C (n = 126, NT-proBNP level > 10,000 pg/mL). Results: Patients hospitalized with decompensated HF and very high levels of NTproBNP, above 10,000 pg/mL at admission, are older, have a lower LVEF, higher NYHA class, more renal dysfunction, and longer hospital stay, resulting in a more severe clinical profile. Conclusions: The presence of very high levels of NT-proBNP may identify a category of patients with a more severe prognosis that requires more aggressive management and closer follow-up. |
| format | Article |
| id | doaj-art-b099d6b52f2f4ca8870e37c579285de7 |
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| issn | 2075-4418 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-b099d6b52f2f4ca8870e37c579285de72025-08-20T02:07:59ZengMDPI AGDiagnostics2075-44182024-11-011422250710.3390/diagnostics14222507Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP LevelsRuxandra Maria Christodorescu0Daniel Miron Brie1Alina Diduța Brie2Samuel Nistor3Alexandru Tîrziu4Angela Dragomir5Cristian Mornoș6Simona Drăgan7Daniel Duda-Seiman8Adina Pop-Moldovan9Dan Dărăbanțiu10Department of Internal Medicine, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaResearch Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, RomaniaDepartment of Cell and Molecular Biology, “Victor Babes” University of Medicine and Pharmacy, Tudor Vladimirescu Street, No. 14, 300174 Timisoara, RomaniaCardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, RomaniaCardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, RomaniaResearch Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, RomaniaResearch Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, RomaniaResearch Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, RomaniaResearch Center of the Institute of Cardiovascular Diseases, Cardiovascular Disease Institute Timisoara, Gheorghe Adam St., No. 13A, 300310 Timisoara, RomaniaFaculty of Medicine, “Vasile Goldis” Western University of Arad, Revolutiei Bvd., No. 174, 310025 Arad, RomaniaArad County Emergency Clinical Hospital, 310158 Arad, RomaniaBackground: NT-proBNP levels with a wide range at admission play both a diagnostic and a prognostic role in patients with HF. The differences regarding the clinical profiles and demography in decompensated HF patients according to NT-proBNP levels at admission are not clear. Methods: This study aimed to analyze and compare clinical profiles and demographics in patients hospitalized for decompensated heart failure according to levels of NT-proBNP at admission. The study included 302 patients hospitalized for decompensated HF who were divided into three groups based on admission NT-proBNP levels: group A (n = 46, with NT-proBNP level < 3000 pg/mL), group B (n = 130, NT-proBNP level between 3000–10,000 pg/mL), and group C (n = 126, NT-proBNP level > 10,000 pg/mL). Results: Patients hospitalized with decompensated HF and very high levels of NTproBNP, above 10,000 pg/mL at admission, are older, have a lower LVEF, higher NYHA class, more renal dysfunction, and longer hospital stay, resulting in a more severe clinical profile. Conclusions: The presence of very high levels of NT-proBNP may identify a category of patients with a more severe prognosis that requires more aggressive management and closer follow-up.https://www.mdpi.com/2075-4418/14/22/2507heart failurebiomarkersNT-proBNP levelrisk factors |
| spellingShingle | Ruxandra Maria Christodorescu Daniel Miron Brie Alina Diduța Brie Samuel Nistor Alexandru Tîrziu Angela Dragomir Cristian Mornoș Simona Drăgan Daniel Duda-Seiman Adina Pop-Moldovan Dan Dărăbanțiu Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP Levels Diagnostics heart failure biomarkers NT-proBNP level risk factors |
| title | Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP Levels |
| title_full | Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP Levels |
| title_fullStr | Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP Levels |
| title_full_unstemmed | Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP Levels |
| title_short | Clinical and Demographic Characteristics of Patients Hospitalized for Decompensated Heart Failure with Extremely High NT-proBNP Levels |
| title_sort | clinical and demographic characteristics of patients hospitalized for decompensated heart failure with extremely high nt probnp levels |
| topic | heart failure biomarkers NT-proBNP level risk factors |
| url | https://www.mdpi.com/2075-4418/14/22/2507 |
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