Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care
IntroductionPolygenic risk scores (PRS) have emerged as a promising tool for refining cardiovascular risk prediction, yet their real-world impact on physician decision-making remains unclear. This study aimed to evaluate how the integration of a coronary artery disease (CAD) PRS with traditional cli...
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| Format: | Article |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2025.1625822/full |
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| author | Georgios Ntritsos Georgios Ntritsos Erez Ornan Nir Gamliel Gil Chernin Arnold Pallay Michael Chen Efi Kessous Eran Feldhay |
| author_facet | Georgios Ntritsos Georgios Ntritsos Erez Ornan Nir Gamliel Gil Chernin Arnold Pallay Michael Chen Efi Kessous Eran Feldhay |
| author_sort | Georgios Ntritsos |
| collection | DOAJ |
| description | IntroductionPolygenic risk scores (PRS) have emerged as a promising tool for refining cardiovascular risk prediction, yet their real-world impact on physician decision-making remains unclear. This study aimed to evaluate how the integration of a coronary artery disease (CAD) PRS with traditional clinical risk factors influences physician management strategies.MethodsWe conducted a multicenter, prospective, open-label pilot study across three clinical sites. A total of 150 patients (aged 18–55 years, LDL-C ≤130 mg/dL, no history of diabetes or coronary artery disease) were recruited. Buccal swabs were collected for PRS analysis, and results were integrated with clinical data to generate personalized risk profiles. Physicians utilized these profiles during consultations and completed structured feedback surveys assessing PRS influence on their clinical decisions.ResultsPRS findings impacted clinical decision-making in 67% of cases (100 participants). The most frequent physician response was raising patient awareness and offering patient education (73 cases), while emphasizing PRS as a tool for risk communication. In 4 specific cases, PRS findings led to new statin recommendations, while 23 cases resulted in other management modifications, including lifestyle adjustments and increased risk monitoring.DiscussionThese findings highlight the potential of PRS in enhancing risk communication and clinical decision-making, primarily by reinforcing patient awareness rather than directly by altering pharmacologic management. Further research is needed to optimize PRS implementation and assess its long-term clinical impact. |
| format | Article |
| id | doaj-art-b09947e1dcd14e29b64cd661c2f4a349 |
| institution | Kabale University |
| issn | 1664-8021 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj-art-b09947e1dcd14e29b64cd661c2f4a3492025-08-20T03:55:48ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-07-011610.3389/fgene.2025.16258221625822Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient careGeorgios Ntritsos0Georgios Ntritsos1Erez Ornan2Nir Gamliel3Gil Chernin4Arnold Pallay5Michael Chen6Efi Kessous7Eran Feldhay8Department of Economics, School of Economics and Management Sciences, University of Ioannina, Ioannina, GreeceOpenDNA, Haifa, IsraelOpenDNA, Haifa, IsraelOpenDNA, Haifa, IsraelFaculty of Medicine, Hebrew University of Jerusalem, Rehovot, IsraelConsensus Medical Group/Atlantic Health System, Montville, NJ, United StatesOpenDNA, Haifa, IsraelOpenDNA, Haifa, IsraelOpenDNA, Haifa, IsraelIntroductionPolygenic risk scores (PRS) have emerged as a promising tool for refining cardiovascular risk prediction, yet their real-world impact on physician decision-making remains unclear. This study aimed to evaluate how the integration of a coronary artery disease (CAD) PRS with traditional clinical risk factors influences physician management strategies.MethodsWe conducted a multicenter, prospective, open-label pilot study across three clinical sites. A total of 150 patients (aged 18–55 years, LDL-C ≤130 mg/dL, no history of diabetes or coronary artery disease) were recruited. Buccal swabs were collected for PRS analysis, and results were integrated with clinical data to generate personalized risk profiles. Physicians utilized these profiles during consultations and completed structured feedback surveys assessing PRS influence on their clinical decisions.ResultsPRS findings impacted clinical decision-making in 67% of cases (100 participants). The most frequent physician response was raising patient awareness and offering patient education (73 cases), while emphasizing PRS as a tool for risk communication. In 4 specific cases, PRS findings led to new statin recommendations, while 23 cases resulted in other management modifications, including lifestyle adjustments and increased risk monitoring.DiscussionThese findings highlight the potential of PRS in enhancing risk communication and clinical decision-making, primarily by reinforcing patient awareness rather than directly by altering pharmacologic management. Further research is needed to optimize PRS implementation and assess its long-term clinical impact.https://www.frontiersin.org/articles/10.3389/fgene.2025.1625822/fullpolygenic risk score (PRS)coronary artery disease (CAD)cardiovascular risk assessmentpersonalized medicinegenetic risk stratificationclinical decision-making |
| spellingShingle | Georgios Ntritsos Georgios Ntritsos Erez Ornan Nir Gamliel Gil Chernin Arnold Pallay Michael Chen Efi Kessous Eran Feldhay Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care Frontiers in Genetics polygenic risk score (PRS) coronary artery disease (CAD) cardiovascular risk assessment personalized medicine genetic risk stratification clinical decision-making |
| title | Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care |
| title_full | Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care |
| title_fullStr | Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care |
| title_full_unstemmed | Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care |
| title_short | Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care |
| title_sort | impact of polygenic risk score prs for coronary artery disease on physician decision making and patient care |
| topic | polygenic risk score (PRS) coronary artery disease (CAD) cardiovascular risk assessment personalized medicine genetic risk stratification clinical decision-making |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2025.1625822/full |
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