Integration of multi-omics profiling reveals an epigenetic-based molecular classification of lung adenocarcinoma: implications for drug sensitivity and immunotherapy response prediction

Integration of multi-omics profiling reveals an epigenetic-based molecular classification of lung adenocarcinoma: implications for drug sensitivity and immunotherapy response prediction

BackgroundLung adenocarcinoma (LUAD) remains a major cause of cancer-related mortality worldwide, with high heterogeneity and poor prognosis. Epigenetic dysregulation plays a crucial role in LUAD progression, yet its potential in molecular classification and therapeutic prediction remains largely un...

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Bibliographic Details
Main Authors: Ning Wang, Yinan Li, Yaoyao Wang, Wenting Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
lung adenocarcinoma
epigenetic regulation
molecular classification
immune microenvironment
precision medicine
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1540477/full
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