Isolated lymphoma of the choroid plexus: a case report
The choroid plexus, pivotal for cerebrospinal fluid (CSF) regulation and blood-CSF barrier function, becomes a focal point for primary central nervous system lymphoma (PCNSL). This article delves into a case of this uncommon presentation, highlighting diagnostic challenges, treatment complexities, a...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2025-05-01
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| Series: | Exploration of Neuroscience |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100689/100689.pdf |
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| author | Ali Msheik Ayman Mawassi Zeinab Al Mokdad |
| author_facet | Ali Msheik Ayman Mawassi Zeinab Al Mokdad |
| author_sort | Ali Msheik |
| collection | DOAJ |
| description | The choroid plexus, pivotal for cerebrospinal fluid (CSF) regulation and blood-CSF barrier function, becomes a focal point for primary central nervous system lymphoma (PCNSL). This article delves into a case of this uncommon presentation, highlighting diagnostic challenges, treatment complexities, and post-treatment outcomes. A 30-year-old Lebanese patient with mild headaches and vomiting was initially diagnosed with vasculitis but later confirmed through endoscopic biopsy to have diffuse large B-cell lymphoma of the choroid plexus. Treatment with intravenous methotrexate, intrathecal cytarabine, rituximab, and radiotherapy led to gradual neurological improvement. Treatment strategies, aligned with PCNSL standards, include intravenous methotrexate, intrathecal cytarabine, rituximab, and radiotherapy, leading to gradual neurological improvement post-treatment. Prognostic factors, such as age and specific brain area involvement, guide tailored treatment plans. This report emphasizes the need for a multidisciplinary approach, increased awareness, and ongoing research for optimal outcomes in PCNSL cases involving the choroid plexus. |
| format | Article |
| id | doaj-art-b08cd2bac2484b7ba237a513f35b2b12 |
| institution | OA Journals |
| issn | 2834-5347 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Neuroscience |
| spelling | doaj-art-b08cd2bac2484b7ba237a513f35b2b122025-08-20T02:26:00ZengOpen Exploration Publishing Inc.Exploration of Neuroscience2834-53472025-05-01410068910.37349/en.2025.100689Isolated lymphoma of the choroid plexus: a case reportAli Msheik0https://orcid.org/0000-0002-4033-1985Ayman Mawassi1Zeinab Al Mokdad2https://orcid.org/0009-0004-7355-9486Neurological Surgery, Hamad Medical Corporation, Doha, QatarGeneral Medicine, Kharkiv National Medical University, 61000 Kharkiv, UkraineBioethics, Lebanese University, Beirut, LebanonThe choroid plexus, pivotal for cerebrospinal fluid (CSF) regulation and blood-CSF barrier function, becomes a focal point for primary central nervous system lymphoma (PCNSL). This article delves into a case of this uncommon presentation, highlighting diagnostic challenges, treatment complexities, and post-treatment outcomes. A 30-year-old Lebanese patient with mild headaches and vomiting was initially diagnosed with vasculitis but later confirmed through endoscopic biopsy to have diffuse large B-cell lymphoma of the choroid plexus. Treatment with intravenous methotrexate, intrathecal cytarabine, rituximab, and radiotherapy led to gradual neurological improvement. Treatment strategies, aligned with PCNSL standards, include intravenous methotrexate, intrathecal cytarabine, rituximab, and radiotherapy, leading to gradual neurological improvement post-treatment. Prognostic factors, such as age and specific brain area involvement, guide tailored treatment plans. This report emphasizes the need for a multidisciplinary approach, increased awareness, and ongoing research for optimal outcomes in PCNSL cases involving the choroid plexus.https://www.explorationpub.com/uploads/Article/A100689/100689.pdfpcnslchoroid plexusintravenous methotrexateintrathecal cytarabine |
| spellingShingle | Ali Msheik Ayman Mawassi Zeinab Al Mokdad Isolated lymphoma of the choroid plexus: a case report Exploration of Neuroscience pcnsl choroid plexus intravenous methotrexate intrathecal cytarabine |
| title | Isolated lymphoma of the choroid plexus: a case report |
| title_full | Isolated lymphoma of the choroid plexus: a case report |
| title_fullStr | Isolated lymphoma of the choroid plexus: a case report |
| title_full_unstemmed | Isolated lymphoma of the choroid plexus: a case report |
| title_short | Isolated lymphoma of the choroid plexus: a case report |
| title_sort | isolated lymphoma of the choroid plexus a case report |
| topic | pcnsl choroid plexus intravenous methotrexate intrathecal cytarabine |
| url | https://www.explorationpub.com/uploads/Article/A100689/100689.pdf |
| work_keys_str_mv | AT alimsheik isolatedlymphomaofthechoroidplexusacasereport AT aymanmawassi isolatedlymphomaofthechoroidplexusacasereport AT zeinabalmokdad isolatedlymphomaofthechoroidplexusacasereport |