Feasibility and impact of Lynch syndrome genetic testing in newly diagnosed colorectal cancer patients: a multicenter observational study in Greece

Feasibility and impact of Lynch syndrome genetic testing in newly diagnosed colorectal cancer patients: a multicenter observational study in Greece

Background: Lynch syndrome (LS) is an autosomal dominant disorder associated with a heightened risk of specific cancers, caused by germline mutations in the mismatch repair (MMR) system, which leads to microsatellite instability (MSI). MSI-positive colorectal cancer (CRC) patients have an increased...

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Main Authors: S. Manolakou, N. Tsoukalas, E. Saloustros, T. Makatsoris, I. Boukovinas, A. Christopoulou, A. Karampeazis, I. Bompolaki, I.-I. Varthalitis, E. Voulgaris, K. Ballasis, A. Boutis, E. Galani, C. Kalofonos, A. Koumarianou, C. Kourousis, P. Papakotoulas, C. Papandreou, E.-I. Perdikouri, A. Andreadou, I. Athanasiadis, F.-I. Dimitrakopoulos, C. Emmanouilidis, E. Kampletsas, O. Katopodi, P. Kosmidis, K. Koutsoukos, E. Lianos, P. Makrantonakis, E. Ntouvelis, C. Panopoulos, V. Papadopoulos, G. Pentheroudakis, E. Samantas, I. Stoupis, G. Tsironis, N. Chatzifoti, I. Souglakos, Z. Saridaki
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:ESMO Gastrointestinal Oncology
Subjects:
Lynch syndrome
colorectal cancer
microsatellite instability
prevention
screening program
preventive oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2949819825000226
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