Evolution of Corneal Collagen Cross-linking
Corneal Collagen crosslinking (CXL) has brought a breakthrough in the field of ophthalmology. CXL strengthens the corneal tissue by utilizing riboflavin (Vitamin B2) which acts as a photosensitizer. CXL has been evolving over many years. The evidence is that it was first proposed for the collagen an...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-04-01
|
| Series: | Delhi Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/DLJO.DLJO_20_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850280033507082240 |
|---|---|
| author | Gunjan Budhiraja |
| author_facet | Gunjan Budhiraja |
| author_sort | Gunjan Budhiraja |
| collection | DOAJ |
| description | Corneal Collagen crosslinking (CXL) has brought a breakthrough in the field of ophthalmology. CXL strengthens the corneal tissue by utilizing riboflavin (Vitamin B2) which acts as a photosensitizer. CXL has been evolving over many years. The evidence is that it was first proposed for the collagen and Elastins over the porcine eyes which demonstrated that it increased the corneal stiffness using a combination of blue light, ultraviolet (UV) light, riboflavin, and sunlight to in-vivo application by Wollensak et al for progressive keratoconus. Mechanism is based upon various photochemical reactions involving riboflavin and photosensitiser as ultraviolet light. Over years there has been various modifications and improvements in understanding of the utility of CXL. Different protocols which have been popularly used are conventional or Dresden protocol evolving into accelerated protocols etc. CXL has been studied by many researchers in various other fields of ophthalmology. Breakthrough was achieved in for infective keratitis (PACK-CXL). Future of CXL and potential is ever evolving and can be studied more extensively in myopia control and various other fields of opthalmology with more safety measures and predictable results in the armamentorium of the opthalmologists. |
| format | Article |
| id | doaj-art-b084f6801d1e4f13ba99b4decdd76c6a |
| institution | OA Journals |
| issn | 0972-0200 2454-2784 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delhi Journal of Ophthalmology |
| spelling | doaj-art-b084f6801d1e4f13ba99b4decdd76c6a2025-08-20T01:48:54ZengWolters Kluwer Medknow PublicationsDelhi Journal of Ophthalmology0972-02002454-27842023-04-0133214314810.4103/DLJO.DLJO_20_23Evolution of Corneal Collagen Cross-linkingGunjan BudhirajaCorneal Collagen crosslinking (CXL) has brought a breakthrough in the field of ophthalmology. CXL strengthens the corneal tissue by utilizing riboflavin (Vitamin B2) which acts as a photosensitizer. CXL has been evolving over many years. The evidence is that it was first proposed for the collagen and Elastins over the porcine eyes which demonstrated that it increased the corneal stiffness using a combination of blue light, ultraviolet (UV) light, riboflavin, and sunlight to in-vivo application by Wollensak et al for progressive keratoconus. Mechanism is based upon various photochemical reactions involving riboflavin and photosensitiser as ultraviolet light. Over years there has been various modifications and improvements in understanding of the utility of CXL. Different protocols which have been popularly used are conventional or Dresden protocol evolving into accelerated protocols etc. CXL has been studied by many researchers in various other fields of ophthalmology. Breakthrough was achieved in for infective keratitis (PACK-CXL). Future of CXL and potential is ever evolving and can be studied more extensively in myopia control and various other fields of opthalmology with more safety measures and predictable results in the armamentorium of the opthalmologists.https://journals.lww.com/10.4103/DLJO.DLJO_20_23collagen cross-linkingkeratoconusprogressionriboflavin |
| spellingShingle | Gunjan Budhiraja Evolution of Corneal Collagen Cross-linking Delhi Journal of Ophthalmology collagen cross-linking keratoconus progression riboflavin |
| title | Evolution of Corneal Collagen Cross-linking |
| title_full | Evolution of Corneal Collagen Cross-linking |
| title_fullStr | Evolution of Corneal Collagen Cross-linking |
| title_full_unstemmed | Evolution of Corneal Collagen Cross-linking |
| title_short | Evolution of Corneal Collagen Cross-linking |
| title_sort | evolution of corneal collagen cross linking |
| topic | collagen cross-linking keratoconus progression riboflavin |
| url | https://journals.lww.com/10.4103/DLJO.DLJO_20_23 |
| work_keys_str_mv | AT gunjanbudhiraja evolutionofcornealcollagencrosslinking |