Expanding the landscape of aging via orbitrap astral mass spectrometry and tandem mass tag integration

Abstract Aging results in a progressive decline in physiological function due to the deterioration of essential biological processes. While proteomics offers insights into aging mechanisms, prior studies are limited in proteome coverage and lifespan range. To address this, we integrate the Orbitrap...

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Bibliographic Details
Main Authors: Gregory R. Keele, Yue Dou, Seth P. Kodikara, Erin D. Jeffery, Dina L. Bai, Erik Hultenius, Zichen Gao, Joao A. Paulo, Steven P. Gygi, Xiao Tian, Tian Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60022-x
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