Clinical Values of Serum Platelet-Activating Factor in Hypertensive Disorders Complicating Pregnancy
Introduction: Serum platelet-activating factor (PAF) was proven to be associated with gestational hypertension. However, the predictive value of serum PAF at early pregnancy for the occurrence and outcomes of hypertensive disorders complicating pregnancy (HDCP) remained unclear. Methods:...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2025-01-01
|
| Series: | Kidney & Blood Pressure Research |
| Online Access: | https://karger.com/article/doi/10.1159/000543242 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850133608311816192 |
|---|---|
| author | Shasha Liu Qianyu Lan Weiling Li Jiefang Zhang Liman Fu Yanlei Xu Yuan Li |
| author_facet | Shasha Liu Qianyu Lan Weiling Li Jiefang Zhang Liman Fu Yanlei Xu Yuan Li |
| author_sort | Shasha Liu |
| collection | DOAJ |
| description |
Introduction: Serum platelet-activating factor (PAF) was proven to be associated with gestational hypertension. However, the predictive value of serum PAF at early pregnancy for the occurrence and outcomes of hypertensive disorders complicating pregnancy (HDCP) remained unclear. Methods: The demographic and clinical characteristics of patients were compared among the different subgroups. The serum PAF level was determined using an enzyme-linked immunosorbent assay. The predictive value of serum PAF for the occurrence and outcomes of HDCP was evaluated using receiver operating characteristic curve analysis. The correlation of serum PAF with blood pressure was assessed using Spearman analysis. Results: Both systolic blood pressure and diastolic blood pressure were significantly higher in HDCP patients, as well as the serum levels of TNF-α and IL-1β at diagnosis/enrollment, while serum levels of IL-10 showed the opposite trend. Serum PAF levels were significantly higher in patients with HDCP compared to normal pregnant women. Furthermore, serum PAF levels were higher in HDCP patients with mild preeclampsia compared to those with gestational hypertension and even more elevated in HDCP patients with severe preeclampsia at the early pregnancy stage and at diagnosis. In HDCP patients, increased serum PAF levels at early pregnancy and at diagnosis were associated with poor outcomes. Additionally, serum PAF levels could predict the occurrence of HDCP and poor outcomes. Conclusion: Serum PAF from HDCP patients at both the early pregnancy and diagnosis stages could effectively predict the occurrence and outcome of HDCP. |
| format | Article |
| id | doaj-art-b07d49be40e44ee493d80e9d9b1260d7 |
| institution | OA Journals |
| issn | 1423-0143 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj-art-b07d49be40e44ee493d80e9d9b1260d72025-08-20T02:31:55ZengKarger PublishersKidney & Blood Pressure Research1423-01432025-01-0150115116010.1159/000543242Clinical Values of Serum Platelet-Activating Factor in Hypertensive Disorders Complicating PregnancyShasha LiuQianyu LanWeiling LiJiefang ZhangLiman FuYanlei XuYuan Li Introduction: Serum platelet-activating factor (PAF) was proven to be associated with gestational hypertension. However, the predictive value of serum PAF at early pregnancy for the occurrence and outcomes of hypertensive disorders complicating pregnancy (HDCP) remained unclear. Methods: The demographic and clinical characteristics of patients were compared among the different subgroups. The serum PAF level was determined using an enzyme-linked immunosorbent assay. The predictive value of serum PAF for the occurrence and outcomes of HDCP was evaluated using receiver operating characteristic curve analysis. The correlation of serum PAF with blood pressure was assessed using Spearman analysis. Results: Both systolic blood pressure and diastolic blood pressure were significantly higher in HDCP patients, as well as the serum levels of TNF-α and IL-1β at diagnosis/enrollment, while serum levels of IL-10 showed the opposite trend. Serum PAF levels were significantly higher in patients with HDCP compared to normal pregnant women. Furthermore, serum PAF levels were higher in HDCP patients with mild preeclampsia compared to those with gestational hypertension and even more elevated in HDCP patients with severe preeclampsia at the early pregnancy stage and at diagnosis. In HDCP patients, increased serum PAF levels at early pregnancy and at diagnosis were associated with poor outcomes. Additionally, serum PAF levels could predict the occurrence of HDCP and poor outcomes. Conclusion: Serum PAF from HDCP patients at both the early pregnancy and diagnosis stages could effectively predict the occurrence and outcome of HDCP. https://karger.com/article/doi/10.1159/000543242 |
| spellingShingle | Shasha Liu Qianyu Lan Weiling Li Jiefang Zhang Liman Fu Yanlei Xu Yuan Li Clinical Values of Serum Platelet-Activating Factor in Hypertensive Disorders Complicating Pregnancy Kidney & Blood Pressure Research |
| title | Clinical Values of Serum Platelet-Activating Factor in Hypertensive Disorders Complicating Pregnancy |
| title_full | Clinical Values of Serum Platelet-Activating Factor in Hypertensive Disorders Complicating Pregnancy |
| title_fullStr | Clinical Values of Serum Platelet-Activating Factor in Hypertensive Disorders Complicating Pregnancy |
| title_full_unstemmed | Clinical Values of Serum Platelet-Activating Factor in Hypertensive Disorders Complicating Pregnancy |
| title_short | Clinical Values of Serum Platelet-Activating Factor in Hypertensive Disorders Complicating Pregnancy |
| title_sort | clinical values of serum platelet activating factor in hypertensive disorders complicating pregnancy |
| url | https://karger.com/article/doi/10.1159/000543242 |
| work_keys_str_mv | AT shashaliu clinicalvaluesofserumplateletactivatingfactorinhypertensivedisorderscomplicatingpregnancy AT qianyulan clinicalvaluesofserumplateletactivatingfactorinhypertensivedisorderscomplicatingpregnancy AT weilingli clinicalvaluesofserumplateletactivatingfactorinhypertensivedisorderscomplicatingpregnancy AT jiefangzhang clinicalvaluesofserumplateletactivatingfactorinhypertensivedisorderscomplicatingpregnancy AT limanfu clinicalvaluesofserumplateletactivatingfactorinhypertensivedisorderscomplicatingpregnancy AT yanleixu clinicalvaluesofserumplateletactivatingfactorinhypertensivedisorderscomplicatingpregnancy AT yuanli clinicalvaluesofserumplateletactivatingfactorinhypertensivedisorderscomplicatingpregnancy |