Assessment of Renal Function in Women with Preeclampsia by Measuring of Serum Cystatin C Level

Background: Preeclampsia (PE) is a major health problem that increases the risk of renal impairment during pregnancy. Studies have described the utility of Cystatin C as a better indicator of kidney function during pregnancy compared to urea, creatinine, or uric acid. Objective: The objective of the...

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Main Authors: Marwa Basim Yarmurad, Miami Abdul Hassan Ali
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Mustansiriya Medical Journal
Subjects:
Online Access:https://journals.lww.com/10.4103/mj.mj_4_24
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author Marwa Basim Yarmurad
Miami Abdul Hassan Ali
author_facet Marwa Basim Yarmurad
Miami Abdul Hassan Ali
author_sort Marwa Basim Yarmurad
collection DOAJ
description Background: Preeclampsia (PE) is a major health problem that increases the risk of renal impairment during pregnancy. Studies have described the utility of Cystatin C as a better indicator of kidney function during pregnancy compared to urea, creatinine, or uric acid. Objective: The objective of the study was to evaluate cystatin C as a diagnostic tool for renal impairment in women with severe PE and compare it to standard renal function tests. Patients and Methods: A case–control study was conducted at Al Yarmouk Teaching Hospital, Bagdad. From March 1, 2022, to September 1, 2022, 94 3rd-trimester pregnant women with newly diagnosed or a history of PE were included in the study and interviewed and subsequently divided into three groups. The GraphPad Prism Software was used for data analysis and graphical presentations in addition to SPSS version 28; 0.05 was selected as a cutoff point for statistical significance. Results: The mean of cystatin C for control 0.39 ± 0.15 was significantly lower than for severe PE 1.12 ± 0.53, P < 0.001. The mean cystatin C for mild PE 0.52 ± 0.13 was considerably lower than for severe PE 1.12 ± 0.53, P < 0.001. Conclusions: Patients with severe PE had higher serum cystatin C than patients with mild PE and healthy normotensive pregnant females. Serum cystatin C at a cutoff value of >0.61 had higher diagnostic accuracy than the other standard kidney tests (urea, creatinine, and uric acid), with a sensitivity and specificity of 90.32% and 93.75%, respectively.
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spelling doaj-art-b07abaa8a7624dd59570e852f4c762642025-01-14T06:48:51ZengWolters Kluwer Medknow PublicationsMustansiriya Medical Journal2070-11282227-40812024-12-01232909410.4103/mj.mj_4_24Assessment of Renal Function in Women with Preeclampsia by Measuring of Serum Cystatin C LevelMarwa Basim YarmuradMiami Abdul Hassan AliBackground: Preeclampsia (PE) is a major health problem that increases the risk of renal impairment during pregnancy. Studies have described the utility of Cystatin C as a better indicator of kidney function during pregnancy compared to urea, creatinine, or uric acid. Objective: The objective of the study was to evaluate cystatin C as a diagnostic tool for renal impairment in women with severe PE and compare it to standard renal function tests. Patients and Methods: A case–control study was conducted at Al Yarmouk Teaching Hospital, Bagdad. From March 1, 2022, to September 1, 2022, 94 3rd-trimester pregnant women with newly diagnosed or a history of PE were included in the study and interviewed and subsequently divided into three groups. The GraphPad Prism Software was used for data analysis and graphical presentations in addition to SPSS version 28; 0.05 was selected as a cutoff point for statistical significance. Results: The mean of cystatin C for control 0.39 ± 0.15 was significantly lower than for severe PE 1.12 ± 0.53, P < 0.001. The mean cystatin C for mild PE 0.52 ± 0.13 was considerably lower than for severe PE 1.12 ± 0.53, P < 0.001. Conclusions: Patients with severe PE had higher serum cystatin C than patients with mild PE and healthy normotensive pregnant females. Serum cystatin C at a cutoff value of >0.61 had higher diagnostic accuracy than the other standard kidney tests (urea, creatinine, and uric acid), with a sensitivity and specificity of 90.32% and 93.75%, respectively.https://journals.lww.com/10.4103/mj.mj_4_24cystatinpreeclampsiapregnancyrenal impairment
spellingShingle Marwa Basim Yarmurad
Miami Abdul Hassan Ali
Assessment of Renal Function in Women with Preeclampsia by Measuring of Serum Cystatin C Level
Mustansiriya Medical Journal
cystatin
preeclampsia
pregnancy
renal impairment
title Assessment of Renal Function in Women with Preeclampsia by Measuring of Serum Cystatin C Level
title_full Assessment of Renal Function in Women with Preeclampsia by Measuring of Serum Cystatin C Level
title_fullStr Assessment of Renal Function in Women with Preeclampsia by Measuring of Serum Cystatin C Level
title_full_unstemmed Assessment of Renal Function in Women with Preeclampsia by Measuring of Serum Cystatin C Level
title_short Assessment of Renal Function in Women with Preeclampsia by Measuring of Serum Cystatin C Level
title_sort assessment of renal function in women with preeclampsia by measuring of serum cystatin c level
topic cystatin
preeclampsia
pregnancy
renal impairment
url https://journals.lww.com/10.4103/mj.mj_4_24
work_keys_str_mv AT marwabasimyarmurad assessmentofrenalfunctioninwomenwithpreeclampsiabymeasuringofserumcystatinclevel
AT miamiabdulhassanali assessmentofrenalfunctioninwomenwithpreeclampsiabymeasuringofserumcystatinclevel