Evaluating the Significance of Inspiratory Volumes and Capacity in Chronic Obstructive Pulmonary Disease
Background: Smoking-induced Chronic obstructive pulmonary disease (COPD) is a chronic lung condition causing airflow obstruction and inflammation, leading to symptoms like breathlessness and fatigue. While expiratory issues are well-studied, the impact of inspiratory function on symptoms is less un...
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Health Research Institute (HRI), National Institute of Health (NIH)
2025-07-01
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| Series: | Pakistan Journal of Medical Research |
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| Online Access: | https://pjmr.org.pk/index.php/pjmr/article/view/1122 |
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| author | Maham Mazhar Bushra Iftikhar Jawaria Muhammad Maria Muddassir Ahmad Basirat Tahir Maqbool Faheem Hadi |
| author_facet | Maham Mazhar Bushra Iftikhar Jawaria Muhammad Maria Muddassir Ahmad Basirat Tahir Maqbool Faheem Hadi |
| author_sort | Maham Mazhar |
| collection | DOAJ |
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Background: Smoking-induced Chronic obstructive pulmonary disease (COPD) is a chronic lung condition causing airflow obstruction and inflammation, leading to symptoms like breathlessness and fatigue. While expiratory issues are well-studied, the impact of inspiratory function on symptoms is less understood.
Objective: To measure inspiratory volumes and capacities, as well to establish a relationship between these variables and clinical characteristics of COPD.
Study type, settings & duration: This cross-sectional study performed at Mayo Hospital, Lahore from March to October 2022.
Methodology: A total of 320 samples were divided into two groups, i.e., COPD and healthy control. Spirometry was performed to correlate lung function with serum SPD levels. We developed a regression model to assess the relative contribution of each variable to the inspiratory functions. Data was analyzed by using Statistical Package for Social Sciences (SPSS) version 16. Continuous metric variables will be described as mean ±SD.
Results: Of the 320 samples, 192 were from males (60%) and 128 (40%) were from females. Mean age of individuals in study was 45±6.11 year. The level of peak inspiratory flow rates among COPD patients (2.15±0.98) were lower (p =0.000) as compared to healthy control (4.06±1.33). Likewise, PIF% predicted was lowered (p =0.000) in COPD (26.91±11.90) as compared to healthy controls (45.67±16.17). Forced inspiratory vital capacity was lowered (p =0.000) among COPD (1.99±0.80) as compared with the control (3.40±0.87) group.
Conclusion: The study suggests that inspiratory volumes and capacities are crucial for hospital admission, diagnosis, management, and staging of COPD. These metrics are significantly lower ........
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| format | Article |
| id | doaj-art-b07604b88e704c409aa85152576ddd89 |
| institution | Kabale University |
| issn | 0030-9842 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Health Research Institute (HRI), National Institute of Health (NIH) |
| record_format | Article |
| series | Pakistan Journal of Medical Research |
| spelling | doaj-art-b07604b88e704c409aa85152576ddd892025-08-20T03:51:13ZengHealth Research Institute (HRI), National Institute of Health (NIH)Pakistan Journal of Medical Research0030-98422025-07-01642Evaluating the Significance of Inspiratory Volumes and Capacity in Chronic Obstructive Pulmonary DiseaseMaham Mazhar0Bushra Iftikhar1Jawaria Muhammad2Maria Muddassir3Ahmad Basirat4Tahir Maqbool5Faheem Hadi6Institute of Molecular Biology and Biotechnology, The University of Lahore. Lahore.Azra Naheed Medical College, Lahore.Tehsil Head Quarter Hospital, Kamonke.M Islam Medical & Dental College, Gujranwala.Department of Respiratory Medicine, Tallaght University Hospital & Peamount Healthcare, Dublin.Tehsil Head Quarter Hospital, Kamonke.The Islamia University of Bahawalpur, Bahawalpur. Background: Smoking-induced Chronic obstructive pulmonary disease (COPD) is a chronic lung condition causing airflow obstruction and inflammation, leading to symptoms like breathlessness and fatigue. While expiratory issues are well-studied, the impact of inspiratory function on symptoms is less understood. Objective: To measure inspiratory volumes and capacities, as well to establish a relationship between these variables and clinical characteristics of COPD. Study type, settings & duration: This cross-sectional study performed at Mayo Hospital, Lahore from March to October 2022. Methodology: A total of 320 samples were divided into two groups, i.e., COPD and healthy control. Spirometry was performed to correlate lung function with serum SPD levels. We developed a regression model to assess the relative contribution of each variable to the inspiratory functions. Data was analyzed by using Statistical Package for Social Sciences (SPSS) version 16. Continuous metric variables will be described as mean ±SD. Results: Of the 320 samples, 192 were from males (60%) and 128 (40%) were from females. Mean age of individuals in study was 45±6.11 year. The level of peak inspiratory flow rates among COPD patients (2.15±0.98) were lower (p =0.000) as compared to healthy control (4.06±1.33). Likewise, PIF% predicted was lowered (p =0.000) in COPD (26.91±11.90) as compared to healthy controls (45.67±16.17). Forced inspiratory vital capacity was lowered (p =0.000) among COPD (1.99±0.80) as compared with the control (3.40±0.87) group. Conclusion: The study suggests that inspiratory volumes and capacities are crucial for hospital admission, diagnosis, management, and staging of COPD. These metrics are significantly lower ........ https://pjmr.org.pk/index.php/pjmr/article/view/1122COPDsmokingexacerbationsregression modelinspiratory volumesexpiratory volumes |
| spellingShingle | Maham Mazhar Bushra Iftikhar Jawaria Muhammad Maria Muddassir Ahmad Basirat Tahir Maqbool Faheem Hadi Evaluating the Significance of Inspiratory Volumes and Capacity in Chronic Obstructive Pulmonary Disease Pakistan Journal of Medical Research COPD smoking exacerbations regression model inspiratory volumes expiratory volumes |
| title | Evaluating the Significance of Inspiratory Volumes and Capacity in Chronic Obstructive Pulmonary Disease |
| title_full | Evaluating the Significance of Inspiratory Volumes and Capacity in Chronic Obstructive Pulmonary Disease |
| title_fullStr | Evaluating the Significance of Inspiratory Volumes and Capacity in Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Evaluating the Significance of Inspiratory Volumes and Capacity in Chronic Obstructive Pulmonary Disease |
| title_short | Evaluating the Significance of Inspiratory Volumes and Capacity in Chronic Obstructive Pulmonary Disease |
| title_sort | evaluating the significance of inspiratory volumes and capacity in chronic obstructive pulmonary disease |
| topic | COPD smoking exacerbations regression model inspiratory volumes expiratory volumes |
| url | https://pjmr.org.pk/index.php/pjmr/article/view/1122 |
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