Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome?
The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex com...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/326032 |
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| _version_ | 1832568099001335808 |
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| author | Alfredo Focà Maria Carla Liberto Angela Quirino Nadia Marascio Emilia Zicca Grazia Pavia |
| author_facet | Alfredo Focà Maria Carla Liberto Angela Quirino Nadia Marascio Emilia Zicca Grazia Pavia |
| author_sort | Alfredo Focà |
| collection | DOAJ |
| description | The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex community in which the virome plays a crucial role into regulation of intestinal immunity and homeostasis. Nevertheless, the size of the human virome is still poorly understood. Indeed the enteric virome is in a continuous and dynamic equilibrium with other components of the gut microbiome and the gut immune system, an interaction that may influence the health and disease of the host. We review recent evidence on the viruses found in the gastrointestinal tract, discussing their interactions with the resident bacterial microbiota and the host immune system, in order to explore the potential impact of the virome on human health. |
| format | Article |
| id | doaj-art-b0754cb6f8c04af5bbaf946bd00f9825 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b0754cb6f8c04af5bbaf946bd00f98252025-02-03T00:59:50ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/326032326032Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome?Alfredo Focà0Maria Carla Liberto1Angela Quirino2Nadia Marascio3Emilia Zicca4Grazia Pavia5Department of Health Sciences, Institute of Microbiology, School of Medicine, University “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, Institute of Microbiology, School of Medicine, University “Magna Graecia”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyThe human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex community in which the virome plays a crucial role into regulation of intestinal immunity and homeostasis. Nevertheless, the size of the human virome is still poorly understood. Indeed the enteric virome is in a continuous and dynamic equilibrium with other components of the gut microbiome and the gut immune system, an interaction that may influence the health and disease of the host. We review recent evidence on the viruses found in the gastrointestinal tract, discussing their interactions with the resident bacterial microbiota and the host immune system, in order to explore the potential impact of the virome on human health.http://dx.doi.org/10.1155/2015/326032 |
| spellingShingle | Alfredo Focà Maria Carla Liberto Angela Quirino Nadia Marascio Emilia Zicca Grazia Pavia Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome? Mediators of Inflammation |
| title | Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome? |
| title_full | Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome? |
| title_fullStr | Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome? |
| title_full_unstemmed | Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome? |
| title_short | Gut Inflammation and Immunity: What Is the Role of the Human Gut Virome? |
| title_sort | gut inflammation and immunity what is the role of the human gut virome |
| url | http://dx.doi.org/10.1155/2015/326032 |
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