High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain.

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain.

Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons. One conopeptide analogue, termed NMB-1 for noxious mechanosensation blocker 1, s...

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Bibliographic Details
Main Authors: Liam J Drew, Francois Rugiero, Paolo Cesare, Jonathan E Gale, Bjarke Abrahamsen, Sarah Bowden, Sebastian Heinzmann, Michelle Robinson, Andreas Brust, Barbara Colless, Richard J Lewis, John N Wood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-06-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000515&type=printable
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