Differential effects of multiplex and uniplex affiliative relationships on biomarkers of inflammation
Social relationships profoundly impact health in social species. Much of what we know regarding the impact of affiliative social relationships on health in nonhuman primates (NHPs) has focused on the structure of connections or the quality of relationships. These relationships are often quantified b...
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PeerJ Inc.
2025-03-01
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| author | Jessica J. Vandeleest Lauren J. Wooddell Amy C. Nathman Brianne Beisner Brenda McCowan |
| author_facet | Jessica J. Vandeleest Lauren J. Wooddell Amy C. Nathman Brianne Beisner Brenda McCowan |
| author_sort | Jessica J. Vandeleest |
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| description | Social relationships profoundly impact health in social species. Much of what we know regarding the impact of affiliative social relationships on health in nonhuman primates (NHPs) has focused on the structure of connections or the quality of relationships. These relationships are often quantified by comparing different types of affiliative behaviors (e.g., contact sitting, grooming, proximity) or pooling affiliative behaviors into an overall measure of affiliation. However, it is unclear how the breadth of affiliative behaviors (e.g., how many different types or which ones) a dyad engages in impact health and fitness outcomes. We used a novel social network approach to quantify the breadth of affiliative relationships based on two behaviors: grooming and sitting in contact. Dyadic relationships were filtered into separate networks depending on whether the pair engaged in multiple affiliative behaviors (multiplex networks) or just one (uniplex networks). Typically, in social network analysis, the edges in the network represent the presence of a single behavior (e.g., grooming) regardless of the presence or absence of other behaviors (e.g., contact sitting, proximity). Therefore, to validate this method, we first compared the overall structure of the standard network for each affiliative behavior: all grooming interactions regardless of contact sitting, and all contact sitting interactions regardless of grooming. We then similarly compared the structure of our filtered multiplex vs. uniplex networks. Results indicated that multiplex networks were more modular, reciprocal, and kin-based while connections in uniplex networks were more strongly associated with social status. These differences were not replicated when comparing networks based on a single behavior alone (i.e., all grooming networks vs. all contact sitting networks). Next, we evaluated whether individual network position in multiplex vs. uniplex (novel approach) or grooming vs. contact sitting (traditional approach) networks differentially impact inflammatory biomarkers in a commonly studied non-human primate model system, the rhesus macaque (Macaca mulatta). Being well connected in multiplex networks (networks where individuals both contact sat and groomed) was associated with lower inflammation (IL-6, TNF-alpha). In contrast, being well connected in uniplex grooming networks (dyad engaged only in grooming and not in contact sitting) was associated with greater inflammation. Altogether, these results suggest that multiplex relationships may function as supportive relationships (e.g., those between kin or strong bonds) that promote health. In contrast, the function of uniplex grooming relationships may be more transactional (e.g., based on social tolerance or social status) and may incur physiological costs. This complexity is important to consider for understanding the mechanisms underlying the association of social relationships on human and animal health. |
| format | Article |
| id | doaj-art-b06a6a67ff7e498d8aeffd6f3a90414c |
| institution | DOAJ |
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| publishDate | 2025-03-01 |
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| spelling | doaj-art-b06a6a67ff7e498d8aeffd6f3a90414c2025-08-20T02:41:52ZengPeerJ Inc.PeerJ2167-83592025-03-0113e1911310.7717/peerj.19113Differential effects of multiplex and uniplex affiliative relationships on biomarkers of inflammationJessica J. Vandeleest0Lauren J. Wooddell1Amy C. Nathman2Brianne Beisner3Brenda McCowan4California National Primate Research Center, University of California, Davis, Davis, CA, United States of AmericaDepartment of Neurosurgery, Emory University, Atlanta, GA, United States of AmericaCalifornia National Primate Research Center, University of California, Davis, Davis, CA, United States of AmericaEmory National Primate Research Center Field Station, Emory University, Lawrenceville, GA, United States of AmericaCalifornia National Primate Research Center, University of California, Davis, Davis, CA, United States of AmericaSocial relationships profoundly impact health in social species. Much of what we know regarding the impact of affiliative social relationships on health in nonhuman primates (NHPs) has focused on the structure of connections or the quality of relationships. These relationships are often quantified by comparing different types of affiliative behaviors (e.g., contact sitting, grooming, proximity) or pooling affiliative behaviors into an overall measure of affiliation. However, it is unclear how the breadth of affiliative behaviors (e.g., how many different types or which ones) a dyad engages in impact health and fitness outcomes. We used a novel social network approach to quantify the breadth of affiliative relationships based on two behaviors: grooming and sitting in contact. Dyadic relationships were filtered into separate networks depending on whether the pair engaged in multiple affiliative behaviors (multiplex networks) or just one (uniplex networks). Typically, in social network analysis, the edges in the network represent the presence of a single behavior (e.g., grooming) regardless of the presence or absence of other behaviors (e.g., contact sitting, proximity). Therefore, to validate this method, we first compared the overall structure of the standard network for each affiliative behavior: all grooming interactions regardless of contact sitting, and all contact sitting interactions regardless of grooming. We then similarly compared the structure of our filtered multiplex vs. uniplex networks. Results indicated that multiplex networks were more modular, reciprocal, and kin-based while connections in uniplex networks were more strongly associated with social status. These differences were not replicated when comparing networks based on a single behavior alone (i.e., all grooming networks vs. all contact sitting networks). Next, we evaluated whether individual network position in multiplex vs. uniplex (novel approach) or grooming vs. contact sitting (traditional approach) networks differentially impact inflammatory biomarkers in a commonly studied non-human primate model system, the rhesus macaque (Macaca mulatta). Being well connected in multiplex networks (networks where individuals both contact sat and groomed) was associated with lower inflammation (IL-6, TNF-alpha). In contrast, being well connected in uniplex grooming networks (dyad engaged only in grooming and not in contact sitting) was associated with greater inflammation. Altogether, these results suggest that multiplex relationships may function as supportive relationships (e.g., those between kin or strong bonds) that promote health. In contrast, the function of uniplex grooming relationships may be more transactional (e.g., based on social tolerance or social status) and may incur physiological costs. This complexity is important to consider for understanding the mechanisms underlying the association of social relationships on human and animal health.https://peerj.com/articles/19113.pdfAffiliationCytokinesInflammationNetworksGroomingMacaca mulatta |
| spellingShingle | Jessica J. Vandeleest Lauren J. Wooddell Amy C. Nathman Brianne Beisner Brenda McCowan Differential effects of multiplex and uniplex affiliative relationships on biomarkers of inflammation PeerJ Affiliation Cytokines Inflammation Networks Grooming Macaca mulatta |
| title | Differential effects of multiplex and uniplex affiliative relationships on biomarkers of inflammation |
| title_full | Differential effects of multiplex and uniplex affiliative relationships on biomarkers of inflammation |
| title_fullStr | Differential effects of multiplex and uniplex affiliative relationships on biomarkers of inflammation |
| title_full_unstemmed | Differential effects of multiplex and uniplex affiliative relationships on biomarkers of inflammation |
| title_short | Differential effects of multiplex and uniplex affiliative relationships on biomarkers of inflammation |
| title_sort | differential effects of multiplex and uniplex affiliative relationships on biomarkers of inflammation |
| topic | Affiliation Cytokines Inflammation Networks Grooming Macaca mulatta |
| url | https://peerj.com/articles/19113.pdf |
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