Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry
Rumination is a transdiagnostic risk factor among adolescents for developing psychopathology. Despite prior research on the neuroscience of rumination in adults, more research is needed regarding the underlying structural neural correlates associated with adolescent rumination. This study analyzed t...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Journal of Mood and Anxiety Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950004425000227 |
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| author | Diane Joss Anna O. Tierney Kristina Pidvirny Nigel M. Jaffe Hannah Goodman Nicholas J. Carson Zev Schuman-Olivier Christian A. Webb |
| author_facet | Diane Joss Anna O. Tierney Kristina Pidvirny Nigel M. Jaffe Hannah Goodman Nicholas J. Carson Zev Schuman-Olivier Christian A. Webb |
| author_sort | Diane Joss |
| collection | DOAJ |
| description | Rumination is a transdiagnostic risk factor among adolescents for developing psychopathology. Despite prior research on the neuroscience of rumination in adults, more research is needed regarding the underlying structural neural correlates associated with adolescent rumination. This study analyzed the neural correlates of trait rumination among adolescents (N = 95) using Voxel-Based Morphometry. We found higher trait rumination was associated with lower gray matter density in the left orbitofrontal cortex, inferior frontal gyrus, dorsolateral prefrontal gyrus, and bilateral temporal gyrus, which are involved in inhibitory control, language processing, executive functioning, and social cognitions, respectively. Additionally, higher trait rumination was also associated with higher gray matter density in the caudate and insula, regions linked to impulsivity and negative emotions. While most of the findings are consistent with prior research on adult depression and rumination, some discrepancies may stem from differences in age and psychopathology severity across study samples. This cross-sectional study provides insights into the neural propensities of adolescent rumination. |
| format | Article |
| id | doaj-art-b069d9a3d8bd47fa8cf02cbce9ee33d4 |
| institution | DOAJ |
| issn | 2950-0044 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Mood and Anxiety Disorders |
| spelling | doaj-art-b069d9a3d8bd47fa8cf02cbce9ee33d42025-08-20T03:09:12ZengElsevierJournal of Mood and Anxiety Disorders2950-00442025-09-011110012510.1016/j.xjmad.2025.100125Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based MorphometryDiane Joss0Anna O. Tierney1Kristina Pidvirny2Nigel M. Jaffe3Hannah Goodman4Nicholas J. Carson5Zev Schuman-Olivier6Christian A. Webb7Center for Mindfulness and Compassion, Cambridge Health Alliance, Malden, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Correspondence to: Center for Mindfulness and Compassion, Cambridge Health Alliance, USA.McLean Hospital, 115 Mill Street, Belmont, MA 02478, USAMcLean Hospital, 115 Mill Street, Belmont, MA 02478, USAMcLean Hospital, 115 Mill Street, Belmont, MA 02478, USACenter for Mindfulness and Compassion, Cambridge Health Alliance, Malden, MA, USADepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; Health Equity Research Lab, Cambridge Health Alliance, Cambridge, MA, USACenter for Mindfulness and Compassion, Cambridge Health Alliance, Malden, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USADepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Hospital, 115 Mill Street, Belmont, MA 02478, USARumination is a transdiagnostic risk factor among adolescents for developing psychopathology. Despite prior research on the neuroscience of rumination in adults, more research is needed regarding the underlying structural neural correlates associated with adolescent rumination. This study analyzed the neural correlates of trait rumination among adolescents (N = 95) using Voxel-Based Morphometry. We found higher trait rumination was associated with lower gray matter density in the left orbitofrontal cortex, inferior frontal gyrus, dorsolateral prefrontal gyrus, and bilateral temporal gyrus, which are involved in inhibitory control, language processing, executive functioning, and social cognitions, respectively. Additionally, higher trait rumination was also associated with higher gray matter density in the caudate and insula, regions linked to impulsivity and negative emotions. While most of the findings are consistent with prior research on adult depression and rumination, some discrepancies may stem from differences in age and psychopathology severity across study samples. This cross-sectional study provides insights into the neural propensities of adolescent rumination.http://www.sciencedirect.com/science/article/pii/S2950004425000227AdolescentRuminationVBMNeural developmentMRITransdiagnostic |
| spellingShingle | Diane Joss Anna O. Tierney Kristina Pidvirny Nigel M. Jaffe Hannah Goodman Nicholas J. Carson Zev Schuman-Olivier Christian A. Webb Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry Journal of Mood and Anxiety Disorders Adolescent Rumination VBM Neural development MRI Transdiagnostic |
| title | Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry |
| title_full | Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry |
| title_fullStr | Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry |
| title_full_unstemmed | Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry |
| title_short | Neural propensity for trait rumination in adolescents: A cross-sectional study with Voxel-Based Morphometry |
| title_sort | neural propensity for trait rumination in adolescents a cross sectional study with voxel based morphometry |
| topic | Adolescent Rumination VBM Neural development MRI Transdiagnostic |
| url | http://www.sciencedirect.com/science/article/pii/S2950004425000227 |
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