Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs.

Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs.

MicroRNAs regulate networks of genes to orchestrate cellular functions. MiR-125b, the vertebrate homologue of the Caenorhabditis elegans microRNA lin-4, has been implicated in the regulation of neural and hematopoietic stem cell homeostasis, analogous to how lin-4 regulates stem cells in C. elegans....

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Main Authors: Minh T N Le, Ng Shyh-Chang, Swea Ling Khaw, Lingzi Chin, Cathleen Teh, Junliang Tay, Elizabeth O'Day, Vladimir Korzh, Henry Yang, Ashish Lal, Judy Lieberman, Harvey F Lodish, Bing Lim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002242&type=printable
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