Evaluating the effectiveness of topical olive leaf extract emulgel in managing recurrent herpes labialis: a randomized controlled clinical study
Abstract Recurrent herpes labialis (RHL) is a lifelong oral health issue that affects about one-third of the world’s population, causing frequent, painful, and discomfort lesions. This randomized, triple-blinded study aimed to evaluate the effectiveness of olive leaf extract (OLE) compared to acyclo...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-81805-0 |
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| author | Mai Adnan Gaizeh Al-Hallak Jamileh Ali Hsaian Abeer Ahmad Aljoujou |
| author_facet | Mai Adnan Gaizeh Al-Hallak Jamileh Ali Hsaian Abeer Ahmad Aljoujou |
| author_sort | Mai Adnan Gaizeh Al-Hallak |
| collection | DOAJ |
| description | Abstract Recurrent herpes labialis (RHL) is a lifelong oral health issue that affects about one-third of the world’s population, causing frequent, painful, and discomfort lesions. This randomized, triple-blinded study aimed to evaluate the effectiveness of olive leaf extract (OLE) compared to acyclovir cream (Veramid 5%) in managing vesicular stage of RHL lesions. Forty patients were randomly divided into two equal groups and were instructed to apply the prescribed medication five times a day for five consecutive days. The evaluation was carried out by measuring the pain intensity on the first day before the treatment was applied (T0), 48 h (T1), and 7 days later (T2). Additionally, the day when the pain completely healed and the day when the lesion’s crust fell off spontaneously were recorded. Statistical analysis was conducted using the Mann-Whitney test at a significance level of α = 0.05. The study results indicated that there were no significant differences in pain intensity between the two groups during the three evaluation times: T0 (P = 920), T1 (P = 0.596), and T2 (P = 1.00). Furthermore, there was no significant difference in the day when the pain was completely healed (P = 0.697). However, the OLE showed a statistically significant advantage regarding the day the lesions’ crust fell off (P = 0.040). In conclusion, OLE may be a potential alternative treatment for RHL. Trial registration: isrctn.com ID: ISRCTN87606522, 04/09/2023. |
| format | Article |
| id | doaj-art-b060f7de336342dca2f7d6d365fe29f8 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-b060f7de336342dca2f7d6d365fe29f82025-08-20T02:30:54ZengNature PortfolioScientific Reports2045-23222024-12-011411810.1038/s41598-024-81805-0Evaluating the effectiveness of topical olive leaf extract emulgel in managing recurrent herpes labialis: a randomized controlled clinical studyMai Adnan Gaizeh Al-Hallak0Jamileh Ali Hsaian1Abeer Ahmad Aljoujou2Faculty of Dentistry, Oral Medicine Department, Damascus University, Damascus UniversityDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus/Syria University, Damascus University and Yarmouk Private UniversityFaculty of Dentistry, Oral Medicine Department, Damascus University, Damascus UniversityAbstract Recurrent herpes labialis (RHL) is a lifelong oral health issue that affects about one-third of the world’s population, causing frequent, painful, and discomfort lesions. This randomized, triple-blinded study aimed to evaluate the effectiveness of olive leaf extract (OLE) compared to acyclovir cream (Veramid 5%) in managing vesicular stage of RHL lesions. Forty patients were randomly divided into two equal groups and were instructed to apply the prescribed medication five times a day for five consecutive days. The evaluation was carried out by measuring the pain intensity on the first day before the treatment was applied (T0), 48 h (T1), and 7 days later (T2). Additionally, the day when the pain completely healed and the day when the lesion’s crust fell off spontaneously were recorded. Statistical analysis was conducted using the Mann-Whitney test at a significance level of α = 0.05. The study results indicated that there were no significant differences in pain intensity between the two groups during the three evaluation times: T0 (P = 920), T1 (P = 0.596), and T2 (P = 1.00). Furthermore, there was no significant difference in the day when the pain was completely healed (P = 0.697). However, the OLE showed a statistically significant advantage regarding the day the lesions’ crust fell off (P = 0.040). In conclusion, OLE may be a potential alternative treatment for RHL. Trial registration: isrctn.com ID: ISRCTN87606522, 04/09/2023.https://doi.org/10.1038/s41598-024-81805-0Recurrent herpes labialisHerpes simplex virusOlive leaf extractEmulgelAcyclovir |
| spellingShingle | Mai Adnan Gaizeh Al-Hallak Jamileh Ali Hsaian Abeer Ahmad Aljoujou Evaluating the effectiveness of topical olive leaf extract emulgel in managing recurrent herpes labialis: a randomized controlled clinical study Scientific Reports Recurrent herpes labialis Herpes simplex virus Olive leaf extract Emulgel Acyclovir |
| title | Evaluating the effectiveness of topical olive leaf extract emulgel in managing recurrent herpes labialis: a randomized controlled clinical study |
| title_full | Evaluating the effectiveness of topical olive leaf extract emulgel in managing recurrent herpes labialis: a randomized controlled clinical study |
| title_fullStr | Evaluating the effectiveness of topical olive leaf extract emulgel in managing recurrent herpes labialis: a randomized controlled clinical study |
| title_full_unstemmed | Evaluating the effectiveness of topical olive leaf extract emulgel in managing recurrent herpes labialis: a randomized controlled clinical study |
| title_short | Evaluating the effectiveness of topical olive leaf extract emulgel in managing recurrent herpes labialis: a randomized controlled clinical study |
| title_sort | evaluating the effectiveness of topical olive leaf extract emulgel in managing recurrent herpes labialis a randomized controlled clinical study |
| topic | Recurrent herpes labialis Herpes simplex virus Olive leaf extract Emulgel Acyclovir |
| url | https://doi.org/10.1038/s41598-024-81805-0 |
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