An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19.
As the SARS-CoV2 pandemic has progressed, there have been marked geographical differences in the pace and extent of its spread. We evaluated the association of BCG vaccination on morbidity and mortality of SARS-CoV2, adjusted for country-specific responses to the epidemic, demographics and health. S...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0243707&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849337240967184384 |
|---|---|
| author | Lucy Chimoyi Kavindhran Velen Gavin J Churchyard Robert Wallis James J Lewis Salome Charalambous |
| author_facet | Lucy Chimoyi Kavindhran Velen Gavin J Churchyard Robert Wallis James J Lewis Salome Charalambous |
| author_sort | Lucy Chimoyi |
| collection | DOAJ |
| description | As the SARS-CoV2 pandemic has progressed, there have been marked geographical differences in the pace and extent of its spread. We evaluated the association of BCG vaccination on morbidity and mortality of SARS-CoV2, adjusted for country-specific responses to the epidemic, demographics and health. SARS-CoV2 cases and deaths as reported by 31 May 2020 in the World Health Organization situation reports were used. Countries with at least 28 days following the first 100 cases, and available information on BCG were included. We used log-linear regression models to explore associations of cases and deaths with the BCG vaccination policy in each country, adjusted for population size, gross domestic product, proportion aged over 65 years, stringency level measures, testing levels, smoking proportion, and the time difference from date of reporting the 100th case to 31 May 2020. We further looked at the association that might have been found if the analyses were done at earlier time points. The study included 97 countries with 73 having a policy of current BCG vaccination, 13 having previously had BCG vaccination, and 11 having never had BCG vaccination. In a log-linear regression model there was no effect of country-level BCG status on SARS-CoV2 cases or deaths. Univariable log-linear regression models showed a trend towards a weakening of the association over time. We found no statistical evidence for an association between BCG vaccination policy and either SARS-CoV2 morbidity or mortality. We urge countries to rather consider alternative tools with evidence supporting their effectiveness for controlling SARS-CoV2 morbidity and mortality. |
| format | Article |
| id | doaj-art-b05e40d64e174245b4438fbf36da772e |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-b05e40d64e174245b4438fbf36da772e2025-08-20T03:44:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011512e024370710.1371/journal.pone.0243707An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19.Lucy ChimoyiKavindhran VelenGavin J ChurchyardRobert WallisJames J LewisSalome CharalambousAs the SARS-CoV2 pandemic has progressed, there have been marked geographical differences in the pace and extent of its spread. We evaluated the association of BCG vaccination on morbidity and mortality of SARS-CoV2, adjusted for country-specific responses to the epidemic, demographics and health. SARS-CoV2 cases and deaths as reported by 31 May 2020 in the World Health Organization situation reports were used. Countries with at least 28 days following the first 100 cases, and available information on BCG were included. We used log-linear regression models to explore associations of cases and deaths with the BCG vaccination policy in each country, adjusted for population size, gross domestic product, proportion aged over 65 years, stringency level measures, testing levels, smoking proportion, and the time difference from date of reporting the 100th case to 31 May 2020. We further looked at the association that might have been found if the analyses were done at earlier time points. The study included 97 countries with 73 having a policy of current BCG vaccination, 13 having previously had BCG vaccination, and 11 having never had BCG vaccination. In a log-linear regression model there was no effect of country-level BCG status on SARS-CoV2 cases or deaths. Univariable log-linear regression models showed a trend towards a weakening of the association over time. We found no statistical evidence for an association between BCG vaccination policy and either SARS-CoV2 morbidity or mortality. We urge countries to rather consider alternative tools with evidence supporting their effectiveness for controlling SARS-CoV2 morbidity and mortality.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0243707&type=printable |
| spellingShingle | Lucy Chimoyi Kavindhran Velen Gavin J Churchyard Robert Wallis James J Lewis Salome Charalambous An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19. PLoS ONE |
| title | An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19. |
| title_full | An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19. |
| title_fullStr | An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19. |
| title_full_unstemmed | An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19. |
| title_short | An ecological study to evaluate the association of Bacillus Calmette-Guerin (BCG) vaccination on cases of SARS-CoV2 infection and mortality from COVID-19. |
| title_sort | ecological study to evaluate the association of bacillus calmette guerin bcg vaccination on cases of sars cov2 infection and mortality from covid 19 |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0243707&type=printable |
| work_keys_str_mv | AT lucychimoyi anecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT kavindhranvelen anecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT gavinjchurchyard anecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT robertwallis anecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT jamesjlewis anecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT salomecharalambous anecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT lucychimoyi ecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT kavindhranvelen ecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT gavinjchurchyard ecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT robertwallis ecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT jamesjlewis ecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 AT salomecharalambous ecologicalstudytoevaluatetheassociationofbacilluscalmetteguerinbcgvaccinationoncasesofsarscov2infectionandmortalityfromcovid19 |