A High‐Throughput Drug Repurposing Strategy to Treat TBX2 and/or TBX3 Dependent Cancers

A High‐Throughput Drug Repurposing Strategy to Treat TBX2 and/or TBX3 Dependent Cancers

ABSTRACT Background The highly homologous T‐box transcription factors TBX2 and TBX3 are critical for embryonic development, and their overexpression in postnatal tissues contributes to a wide range of malignancies, including melanoma and rhabdomyosarcoma. Importantly, when TBX2 and TBX3 are depleted...

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Bibliographic Details
Main Authors: Jenna S. Bleloch, Sizhu Lu, Saif Feroz Khan, Karabo Serala, Elena Seraia, Val Millar, Daniel Ebner, Colin Goding, Sharon Prince
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Cancer Medicine
Subjects:
drug repurposing
high‐throughput screen
T‐box factors
transcription factors
Online Access:https://doi.org/10.1002/cam4.70303
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