The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target
Circular RNA (circRNA) is a new type of non-coding RNA that has gained significant attention in recent years, especially in tuberculosis research. Tuberculosis poses a major global public health threat. Its complex pathological mechanisms and worsening drug resistance urgently necessitate new resear...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1542686/full |
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| author | Mingyang Hong Xu Huang Huiming Zhu Jiahui Ma Feng Li |
| author_facet | Mingyang Hong Xu Huang Huiming Zhu Jiahui Ma Feng Li |
| author_sort | Mingyang Hong |
| collection | DOAJ |
| description | Circular RNA (circRNA) is a new type of non-coding RNA that has gained significant attention in recent years, especially in tuberculosis research. Tuberculosis poses a major global public health threat. Its complex pathological mechanisms and worsening drug resistance urgently necessitate new research breakthroughs. The role of circRNA in mycobacterium tuberculosis infection is being gradually revealed, highlighting its importance in regulating gene expression, immune response, and inflammation. Additionally, researchers are interested in circRNA because of its potential for early tuberculosis diagnosis and its role as a biomarker. This article systematically analyzes existing literature to provide new insights into early tuberculosis diagnosis and personalized treatment. We also emphasize the need for future research to enhance the application of circRNA in tuberculosis prevention and control. |
| format | Article |
| id | doaj-art-b059dd810ce143ea91b82d18f3b28ea3 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-b059dd810ce143ea91b82d18f3b28ea32025-08-20T03:10:25ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15426861542686The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic targetMingyang Hong0Xu Huang1Huiming Zhu2Jiahui Ma3Feng Li4Department of Clinical Laboratory, Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), Nantong, Jiangsu, ChinaNantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity and Child Healthcare Hospital of Nantong University, Nantong, Jiangsu, ChinaDepartment of Clinical Laboratory, Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), Nantong, Jiangsu, ChinaDepartment of Clinical Laboratory, Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), Nantong, Jiangsu, ChinaDepartment of Clinical Laboratory, Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), Nantong, Jiangsu, ChinaCircular RNA (circRNA) is a new type of non-coding RNA that has gained significant attention in recent years, especially in tuberculosis research. Tuberculosis poses a major global public health threat. Its complex pathological mechanisms and worsening drug resistance urgently necessitate new research breakthroughs. The role of circRNA in mycobacterium tuberculosis infection is being gradually revealed, highlighting its importance in regulating gene expression, immune response, and inflammation. Additionally, researchers are interested in circRNA because of its potential for early tuberculosis diagnosis and its role as a biomarker. This article systematically analyzes existing literature to provide new insights into early tuberculosis diagnosis and personalized treatment. We also emphasize the need for future research to enhance the application of circRNA in tuberculosis prevention and control.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1542686/fullcircular RNAtuberculosisbiomarkersimmune responsetherapeutic |
| spellingShingle | Mingyang Hong Xu Huang Huiming Zhu Jiahui Ma Feng Li The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target Frontiers in Immunology circular RNA tuberculosis biomarkers immune response therapeutic |
| title | The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target |
| title_full | The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target |
| title_fullStr | The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target |
| title_full_unstemmed | The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target |
| title_short | The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target |
| title_sort | role of circular rna in immune response to tuberculosis and its potential as a biomarker and therapeutic target |
| topic | circular RNA tuberculosis biomarkers immune response therapeutic |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1542686/full |
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