Lupus eritematoso sistémico de inicio en la infancia en el Hospital María, Especialidades Pediátricas, 2019-2023
Introduction: Systemic Lupus Erythematosus (SLE) is a complex, multisystemic autoimmune disease with a multifac-torial etiology. Objective: To describe the clinical and laboratory characteristics of patients with childhood-onset SLE treated at the Clinical Management Unit (CMU)...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Colegio Médico de Honduras
2025-06-01
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| Series: | Revista Médica Hondureña |
| Subjects: | |
| Online Access: | https://www.camjol.info/index.php/RMH/article/view/20386 |
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| Summary: | Introduction: Systemic Lupus Erythematosus (SLE) is a complex, multisystemic autoimmune disease with a multifac-torial etiology. Objective: To describe the clinical and laboratory characteristics of patients with childhood-onset SLE treated at the Clinical Management Unit (CMU) of Immunology and Allergy at Hospital María, Especialidades Pediátricas (HMEP). Methods:This was an observational, descriptive, and cross-sectional study. The population included patients diagnosed with SLE who atten-ded the CMU of Immunology and Allergy at HMEP. No sample size calculation was performed. Inclusion criteria were patients under 18 years of age, diagnosis of SLE by a pediatric immu-nologist at HMEP, and disease onset between 2019 and 2023. Descriptive statistics were used for the analysis. The study was approved by the Bioethics Committee of HMEP. Results: A total of 48 patients were analyzed. Females were predominantly affected, with a female-to-male ratio of 15:1. The mean age at diagnosis was 14 years, with adolescents comprising 91.2% of cases. Renal involvement was the most frequent manifestation, affecting 62.5% (30/48) of patients. Positive antinuclear antibodies were observed in 97.9% (47/48), and anti-DNA antibodies were positive in 81.2% (39/48). Hospitalization was required in 66.7% (32/48) of patients due to the severity of their symptoms. The mortality rate was 4.1% (2/48). Discussion: Although SLE in pediatrics is a low-incidence condition, its severity and chronic progression make it imperative to establish an early diagnostic suspicion and ensure timely referral for management. |
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| ISSN: | 0375-1112 1995-7068 |