Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM

IntroductionGlioblastoma (GBM) remains a deadly cancer with non-curative upfront treatment of radiation, resection, and chemotherapy. Not only has the standard of care for GBM patients not improved significantly over the past decade, life expectancy is less than 18 months, with no standard second-li...

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Bibliographic Details
Main Authors:	Danielle R. Cook, Alina C. Boesteanu, Yibo Yin, Reiss Reid, Laura Roccograndi, Nadia Dahmane, Maria Martinez-Lage, Donald M. O’Rourke, Carl H. June, Laura A. Johnson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Immunology
Subjects:	chimeric antigen receptor (CAR) tumor microenvironment (TME) glioblastoma (GBM) checkpoint inhibition (CPI) fourth generation CAR ARMed CAR
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1579925/full
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Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM

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