Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck
The results of the clinical studies have a direct impact on clinical practice. The main criteria for the effectiveness of treatment method are increasing the overall life expectancy and improving its quality. In the treatment of common forms of squamous cell carcinoma of the head and neck, induction...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2020-07-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/522 |
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| author | L. V. Bolotina T. I. Deshkina A. L. Kornietskaya S. A. Kravtsov T. V. Ustinova A. A. Paychadze A. D. Kaprin А. А. Fedenko |
| author_facet | L. V. Bolotina T. I. Deshkina A. L. Kornietskaya S. A. Kravtsov T. V. Ustinova A. A. Paychadze A. D. Kaprin А. А. Fedenko |
| author_sort | L. V. Bolotina |
| collection | DOAJ |
| description | The results of the clinical studies have a direct impact on clinical practice. The main criteria for the effectiveness of treatment method are increasing the overall life expectancy and improving its quality. In the treatment of common forms of squamous cell carcinoma of the head and neck, induction chemotherapy can be used, including platinum drugs, preferably in combination with cetuximab. Next immuno-oncological drugs should be prescribed. In the future, in the 1st line of therapy, it is possible to replace cetuximab with pembrolizumab or monotherapy with pembrolizumab, which allows to increase the effectiveness of treatment and reduce its toxicity. The article presents 3 clinical observations that demonstrate the possibility of integration the results of clinical research in practice. |
| format | Article |
| id | doaj-art-b048da499da94939b7645edc7f4ba6eb |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2020-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-b048da499da94939b7645edc7f4ba6eb2025-08-20T03:59:48ZrusABV-pressОпухоли головы и шеи2222-14682411-46342020-07-01102102110.17650/2222-1468-2020-10-2-10-21388Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neckL. V. Bolotina0T. I. Deshkina1A. L. Kornietskaya2S. A. Kravtsov3T. V. Ustinova4A. A. Paychadze5A. D. Kaprin6А. А. Fedenko7P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaP.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaP.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaCity Clinical Hospital No. 1, Moscow Healthcare DepartmentP.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaP.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaP.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaP.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaThe results of the clinical studies have a direct impact on clinical practice. The main criteria for the effectiveness of treatment method are increasing the overall life expectancy and improving its quality. In the treatment of common forms of squamous cell carcinoma of the head and neck, induction chemotherapy can be used, including platinum drugs, preferably in combination with cetuximab. Next immuno-oncological drugs should be prescribed. In the future, in the 1st line of therapy, it is possible to replace cetuximab with pembrolizumab or monotherapy with pembrolizumab, which allows to increase the effectiveness of treatment and reduce its toxicity. The article presents 3 clinical observations that demonstrate the possibility of integration the results of clinical research in practice.https://ogsh.abvpress.ru/jour/article/view/522squamous cell carcinoma of the head and neckplatinum-based chemotherapyimmuno-oncological drugsnivolumabpembrolizumab1st line drug therapypd-l1 expression |
| spellingShingle | L. V. Bolotina T. I. Deshkina A. L. Kornietskaya S. A. Kravtsov T. V. Ustinova A. A. Paychadze A. D. Kaprin А. А. Fedenko Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck Опухоли головы и шеи squamous cell carcinoma of the head and neck platinum-based chemotherapy immuno-oncological drugs nivolumab pembrolizumab 1st line drug therapy pd-l1 expression |
| title | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_full | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_fullStr | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_full_unstemmed | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_short | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_sort | influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| topic | squamous cell carcinoma of the head and neck platinum-based chemotherapy immuno-oncological drugs nivolumab pembrolizumab 1st line drug therapy pd-l1 expression |
| url | https://ogsh.abvpress.ru/jour/article/view/522 |
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