High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes

High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes

IntroductionSomatotropes lacking leptin receptors (LEPR) produce less growth hormone and are poorly responsive to growth hormone releasing hormone (GHRH). Transcriptomic analysis reveals that the mutant somatotropes contain progenitor cell markers (Sox9+) and multiple pituitary hormone transcripts-(...

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Bibliographic Details
Main Authors: Tiffany K. Miles, Angela K. Odle, Stephanie D. Byrum, Alex N. Lagasse, Anessa C. Haney, Victoria G. Ortega, Ashley K. Herdman, Melanie C. MacNicol, Angus M. MacNicol, Gwen V. Childs
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
pituitary
scRNA-seq
high-fat diet
obesity
leptin
LEPR
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1617109/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1617109/full

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